十六烷基氯化吡啶促进严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒样颗粒的解聚。
Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles.
作者信息
Bañó-Polo Manuel, Martínez-Gil Luis, Sánchez Del Pino Manuel M, Massoli Alberto, Mingarro Ismael, Léon Rubén, Garcia-Murria Maria Jesus
机构信息
Department of Microbiology. Dentaid Research Center, Cerdanyola del Vallès, Barcelona, Spain.
Department of Biochemistry and Molecular Biology, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Valencia, Spain.
出版信息
J Oral Microbiol. 2022 Jan 24;14(1):2030094. doi: 10.1080/20002297.2022.2030094. eCollection 2022.
BACKGROUND
SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory.
AIM OF THE STUDY
To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor.
METHODS
SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations.
RESULTS
Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes.
CONCLUSION
Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.
背景
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）正在全球持续传播。制定阻断传播的策略势在必行。
研究目的
研究氯化十六烷基吡啶（CPC）作为一种病毒抑制剂的潜力。
方法
将SARS-CoV-2病毒样颗粒（VLPs）与CPC一起孵育，CPC是漱口水制剂中常规包含的一种强效表面活性剂。
结果
漱口水制剂中常用的0.05%（w/v）CPC浓度足以促使SARS-CoV-2 VLP膜破裂。
结论
在漱口水中加入CPC可能是一种预防SARS-CoV-2传播的策略。
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