Wade T R, Kopf A W
J Dermatol Surg Oncol. 1978 Jun;4(6):459-64. doi: 10.1111/j.1524-4725.1978.tb00473.x.
Cowden's disease is one of the rare genodermatoses. The most characteristic findings in this disease are cutaneous and oral lesions that are widespread papillomas and verrucous papules. On the palms the lesions are keratoses. Aside from these findings, this syndrome complex is sooner or later associated with various internal abnormalities involving the mammary, thyroid, gastrointestinal, reproductive and skeletal systems. In the 28 reported cases, 13 cancers have been found, most of the breasts. Because of the characteristic cutaneous and oral lesions, it is possible to recognize this disease early and then to follow afflicted patients closely for the possibility of development of cancers or other abnormalities of other organs.
考登病是一种罕见的遗传性皮肤病。该病最典型的表现是皮肤和口腔损害，表现为广泛的乳头状瘤和疣状丘疹。手掌部的损害为角化病。除了这些表现外，该综合征迟早会伴有涉及乳腺、甲状腺、胃肠道、生殖系统和骨骼系统的各种内脏异常。在已报道的28例病例中，发现了13例癌症，其中大多数为乳腺癌。由于其典型的皮肤和口腔损害，有可能早期识别该病，然后密切随访患病患者，以观察是否会发生癌症或其他器官的异常。
