School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.
Faculty of Rehabilitation and Allied Health Sciences, Riphah International University, Islamabad, Pakistan.
Front Immunol. 2022 Jan 14;12:794780. doi: 10.3389/fimmu.2021.794780. eCollection 2021.
Various metabolites identified with therapeutic mushrooms have been found from different sources and are known to have antibacterial, antiviral, and anticancer properties. Over thousands soil growth-based mushroom metabolites have been discovered, and utilized worldwide to combat malignancy. In this study, psilocybin-mushroom that contains the psychedelic compounds such as psilacetin, psilocin, and psilocybine were screened and found to be inhibitors of SARS-CoV-2 Mprotease. It has been found that psilacetin, psilocin, and psilocybine bind to Mprotease with -6.0, -5.4, and -5.8 kcal/mol, respectively. Additionally, the psilacetin was found to inhibit human interleukin-6 receptors to reduce cytokine storm. The binding of psilacetin to Mprotease of SARS-CoV-2 and human interleukin-6 receptors changes the structural dynamics and Gibbs free energy patterns of proteins. These results suggested that psilocybin-mushroom could be utilized as viable potential chemotherapeutic agents for SARS-CoV-2.
从不同来源发现的具有治疗作用的蘑菇的各种代谢物已被证实具有抗菌、抗病毒和抗癌特性。在全球范围内，已经发现了成千上万种基于土壤生长的蘑菇代谢物，并用于对抗恶性肿瘤。在这项研究中，含有迷幻化合物如 psilacetin、psilocin 和 psilocybine 的致幻蘑菇被筛选出来，并被发现是 SARS-CoV-2 Mpro 蛋白酶的抑制剂。研究发现，psilacetin、psilocin 和 psilocybine 分别与 Mpro 蛋白酶结合的亲和力为-6.0、-5.4 和-5.8 kcal/mol。此外，还发现 psilacetin 可以抑制人白细胞介素-6 受体，从而减少细胞因子风暴。psilacetin 与 SARS-CoV-2 的 Mpro 蛋白酶和人白细胞介素-6 受体的结合改变了蛋白质的结构动力学和吉布斯自由能模式。这些结果表明，致幻蘑菇可以作为治疗 SARS-CoV-2 的潜在化疗药物。
Zotero 插件
