Dagogo-Jack S
Department of Medicine, University of Newcastle Upon Tyne, United Kingdom.
Scand J Gastroenterol Suppl. 1986;124:47-54. doi: 10.3109/00365528609093781.
Saliva samples were obtained from volunteers either by spontaneous expectoration or after stimulation with citric acid (5%) and EGF was measured by a homologous radioimmunoassay. The mean +/- SEM of salivary human epidermal growth factor (hEGF) concentration in 70 males (aged 19-41) was 368.71 +/- 28.55 pmol/1 and 417.67 +/- 37.61 pmol/1 in 55 females (aged 19-45), P0.5. Values were found undetectable (32 pmol/1 in 6 prepubertal children. There was a tendency for hEGF to rise with age from about middle age but no significant racial or pregnancy related changes were observed. Stimulated sallivation with citric acid caused a fall in hEGF through a dilution effect. These results show that age has an important influence on the hEGF concentration of resting saliva.
通过自然咳痰或用柠檬酸（5%）刺激后，从志愿者处获取唾液样本，并用同源放射免疫分析法测量表皮生长因子（EGF）。70名男性（年龄19 - 41岁）唾液中人表皮生长因子（hEGF）浓度的平均值±标准误为368.71±28.55 pmol/1，55名女性（年龄19 - 45岁）为417.67±37.61 pmol/1，P0.5。在6名青春期前儿童中未检测到该值（<32 pmol/1）。hEGF有从中年左右开始随年龄增长而升高的趋势，但未观察到明显的种族或与妊娠相关的变化。用柠檬酸刺激唾液分泌会因稀释作用导致hEGF下降。这些结果表明年龄对静息唾液的hEGF浓度有重要影响。
