量化阿尔茨海默病和其他神经病理学的纵向认知弹性。
Quantifying longitudinal cognitive resilience to Alzheimer's disease and other neuropathologies.
机构信息
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
University of Bordeaux, Bordeaux, France.
出版信息
Alzheimers Dement. 2022 Nov;18(11):2252-2261. doi: 10.1002/alz.12576. Epub 2022 Feb 1.
INTRODUCTION
Cognitive resilience (CR) has been defined as the continuum of better (or worse) than expected cognition, given the degree of neuropathology. To quantify this concept, existing approaches focus on either cognitive level at a single time point or slopes of cognitive decline.
METHODS
In a prospective study of 1215 participants, we created a continuous measure of CR defined as the mean of differences between estimated person-specific and marginal cognitive levels over time, after accounting for neuropathologies.
RESULTS
Neuroticism and depressive symptoms were associated with all CR measures (P-values < .012); as expected, cognitive activity and education were only associated with the cognitive-level approaches (P-values < .0002). However, compared with the existing CR measures focusing on a single measure or slopes of cognition, our new measure yielded stronger relations with risk factors.
DISCUSSION
Defining CR based on the longitudinal differences between person-specific and marginal cognitive levels is a novel and complementary way to quantify CR.
简介
认知弹性（CR）已被定义为在给定神经病理学程度的情况下，认知优于（或差于）预期的连续体。为了量化这一概念，现有的方法主要关注单一时间点的认知水平或认知下降的斜率。
方法
在一项对 1215 名参与者的前瞻性研究中，我们创建了一个连续的 CR 衡量标准，该标准定义为在考虑神经病理学后，随着时间的推移，个体特定和边缘认知水平之间差异的平均值。
结果
神经质和抑郁症状与所有 CR 衡量标准都相关（P 值均<0.012）；与预期的一样，认知活动和教育仅与认知水平方法相关（P 值均<0.0002）。然而，与专注于单一衡量标准或认知斜率的现有 CR 衡量标准相比，我们的新衡量标准与风险因素的相关性更强。
讨论
基于个体特定和边缘认知水平之间的纵向差异来定义 CR 是一种量化 CR 的新颖且互补的方法。
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