突触前递质含量控制着神经-神经元胆碱能突触处释放的量子数量。
Presynaptic transmitter content controls the number of quanta released at a neuro-neuronal cholinergic synapse.
作者信息
Poulain B, Baux G, Tauc L
出版信息
Proc Natl Acad Sci U S A. 1986 Jan;83(1):170-3. doi: 10.1073/pnas.83.1.170.
Abstract
In the buccal ganglion of Aplysia the overloading of the cholinergic presynaptic neuron by exogenous acetylcholine (AcCho) led to an enhancement of the postsynaptic response. The deprivation of choline in the presynaptic neuron by extra- and/or intracellularly applied choline oxidase to prevent AcCho synthesis resulted in a decrease of the postsynaptic response. In both cases, the size of the calculated miniature postsynaptic current (i.e., the size of the quantum) remained unchanged. It was concluded that, for a given stimulation, the number of quanta released (i.e., the quantal content) is directly related to the quantity of AcCho available for release in the presynaptic neuron.
摘要
在海兔的颊神经节中，外源性乙酰胆碱（AcCho）使胆碱能突触前神经元过载，导致突触后反应增强。通过细胞外和/或细胞内应用胆碱氧化酶剥夺突触前神经元中的胆碱以阻止AcCho合成，导致突触后反应减弱。在这两种情况下，计算出的微小突触后电流的大小（即量子的大小）保持不变。得出的结论是，对于给定的刺激，释放的量子数量（即量子含量）与突触前神经元中可用于释放的AcCho量直接相关。
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