Hutten Nadia R P W, Mason Natasha L, Dolder Patrick C, Theunissen Eef L, Holze Friederike, Liechti Matthias E, Varghese Nimmy, Eckert Anne, Feilding Amanda, Ramaekers Johannes G, Kuypers Kim P C
Department of Neuropsychology & Psychopharmacology, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht 6200 MD, The Netherlands.
Department of Biomedicine and Department of Clinical Research, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, University of Basel, Basel 4003, Switzerland.
ACS Pharmacol Transl Sci. 2020 Aug 31;4(2):461-466. doi: 10.1021/acsptsci.0c00099. eCollection 2021 Apr 9.
Despite preclinical evidence for psychedelic-induced neuroplasticity, confirmation in humans is grossly lacking. Given the increased interest in using low doses of psychedelics for psychiatric indications and the importance of neuroplasticity in the therapeutic response, this placebo-controlled within-subject study investigated the effect of single low doses of LSD (5, 10, and 20 μg) on circulating BDNF levels in healthy volunteers. Blood samples were collected every 2 h over 6 h, and BDNF levels were determined afterward in blood plasma using ELISA. The findings demonstrated an increase in BDNF blood plasma levels at 4 h (5 μg) and 6 h (5 and 20 μg) compared to that for the placebo. The finding that LSD acutely increases BDNF levels warrants studies in patient populations.
尽管有临床前证据表明迷幻药可诱导神经可塑性，但在人体中的证实却严重不足。鉴于对低剂量迷幻药用于精神疾病适应症的兴趣增加以及神经可塑性在治疗反应中的重要性，这项安慰剂对照的受试者内研究调查了单次低剂量的麦角酸二乙酰胺（LSD，5、10和20微克）对健康志愿者循环脑源性神经营养因子（BDNF）水平的影响。在6小时内每2小时采集一次血样，随后使用酶联免疫吸附测定法（ELISA）测定血浆中的BDNF水平。研究结果表明，与安慰剂相比，在4小时（5微克）和6小时（5和20微克）时血浆中BDNF水平有所升高。LSD能急性增加BDNF水平这一发现值得在患者群体中开展研究。
