Department of Immunopathology, Infectious and Parasitic Diseases, Medical University of Warsaw, Warsaw, Poland.
Department of Adult Infectious Diseases, Medical University of Warsaw, Warsaw, Poland.
Arch Immunol Ther Exp (Warsz). 2022 Feb 3;70(1):7. doi: 10.1007/s00005-021-00641-6.
Disturbances in gastrointestinal (GI) microbiota could play a significant role in the development of GI cancers, but the underlying mechanisms remain largely unclear. While some bacteria seem to facilitate carcinogenesis, others appear to be protective. So far only one bacterium (Helicobacter pylori) has been classified by the International Agency for Cancer Research as carcinogenic in humans but many other are the subject of intense research. Most studies on the role of microbiota in GI tract oncogenesis focus on pancreatic and colorectal cancers with the following three species: Helicobacter pylori, Escherichia coli, and Porphyromonas gingivalis as likely causative factors. This review summarizes the role of bacteria in GI tract oncogenesis.
胃肠道（GI）微生物群的紊乱可能在 GI 癌症的发展中起重要作用，但潜在机制在很大程度上仍不清楚。虽然有些细菌似乎促进了癌变，但有些细菌似乎具有保护作用。到目前为止，国际癌症研究机构仅将一种细菌（幽门螺杆菌）归类为人类致癌细菌，但其他许多细菌仍在进行深入研究。大多数关于微生物群在胃肠道肿瘤发生中的作用的研究都集中在胰腺癌和结直肠癌上，以下三种细菌可能是致癌因素：幽门螺杆菌、大肠杆菌和牙龈卟啉单胞菌。本综述总结了细菌在胃肠道肿瘤发生中的作用。
