Department of Dentistry, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Psychology, University of Maryland, Baltimore, Maryland, USA.
J Clin Periodontol. 2022 Apr;49(4):313-321. doi: 10.1111/jcpe.13599. Epub 2022 Feb 23.
To examine whether baseline periodontal disease is independently associated with incident prediabetes and incident diabetes in Hispanics/Latinos in the United States.
This study examined 7827 individuals, 18-74 years of age without diabetes, from the Hispanic Community Health Study/Study of Latinos. Participants received a full-mouth periodontal examination at baseline (2008-2011), and the disease was classified using the Centers for Disease Control and Prevention/American Academy of Periodontology case definitions. At Visit 2 (2014-2017), incident prediabetes and diabetes were assessed using multiple standard procedures including blood tests. Multivariable survey Poisson regressions estimated the rate ratio (RR) and 95% confidence intervals (CIs) of incident prediabetes and incident diabetes associated with periodontal disease severity.
Among the individuals without prediabetes or diabetes at baseline, 38.8% (n = 1553) had developed prediabetes and 2.2% (n = 87) had developed diabetes after 6 years. Nineteen percent (n = 727) of individuals with prediabetes at baseline developed diabetes after 6 years. Adjusting for all potential confounders, no significant association was found between periodontal disease severity and either incident prediabetes (RR: 0.93; 95% CI: 0.82-1.06) or incident diabetes (RR: 0.99; 95% CI: 0.80-1.22).
Our findings suggest that among a diverse cohort of Hispanic/Latino individuals living in the United States, there was no association between periodontal disease severity and the development of either prediabetes or diabetes during a 6-year follow-up period.
探讨美国西班牙裔/拉丁裔人群中基线牙周病是否与糖尿病前期和糖尿病的发生独立相关。
本研究纳入了 7827 名年龄在 18-74 岁、无糖尿病的西班牙裔社区健康研究/拉丁裔研究参与者。在基线（2008-2011 年）时，所有参与者均接受了全口牙周检查，疾病采用疾病控制与预防中心/美国牙周病学会的病例定义进行分类。在随访 2 时（2014-2017 年），采用包括血液检查在内的多项标准程序评估糖尿病前期和糖尿病的发生情况。多变量调查泊松回归估计了牙周病严重程度与糖尿病前期和糖尿病发生相关的发病率比（RR）及其 95%置信区间（CI）。
在基线时无糖尿病前期或糖尿病的人群中，38.8%（n=1553）出现了糖尿病前期，2.2%（n=87）发展为糖尿病，6 年后的发病率为 2.2%。在基线时患有糖尿病前期的人群中，19%（n=727）在 6 年后发展为糖尿病。在调整了所有潜在混杂因素后，牙周病严重程度与糖尿病前期（RR：0.93；95%CI：0.82-1.06）或糖尿病（RR：0.99；95%CI：0.80-1.22）的发生均无显著相关性。
我们的研究结果表明，在美国生活的多样化西班牙裔/拉丁裔人群中，牙周病严重程度与糖尿病前期或糖尿病的发生在 6 年的随访期间无关联。
