Li Haoran, Wang Yanhua, Zhang Mao, Hu Jie, Li Zixiang, Han Bing
Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266005, China.
Interventioanl Medicine Center, The Affiliated Hospital of Qingdao University, Qingdao 266005, China.
Transl Cancer Res. 2019 Apr;8(2):532-541. doi: 10.21037/tcr.2019.03.09.
In hepatocellular carcinoma (HCC), inflammatory factors play an important role, but their effects on the prognosis of patients with HCC are still not very clear.
Immunohistochemical staining was used to detect the expression of tumor necrosis factor-alpha (TNF-α) and nuclear factor-kappa B (NF-κB) in tumour tissues of Barcelona Clinic Liver Cancer-0-B stage (BCLC-0-B) patients with HCC. The relationship between TNF-α and NF-κB expression and clinicopathological features was analysed by χ test. Kaplan-Meier analysis and the log-rank test were used to compare the prognoses of TNF-α and NF-κB high and low-expression groups among HCC patients. The Cox proportional hazard model was used to analyse HCC prognosis by univariate and multivariate analysis.
Patients with HCC had significantly longer survival times in the TNF-α/NF-κB high-coexpression group (P<0.05). High expression of TNF-α and NF-κB is an independent prognostic factor predicting postoperative survival and recurrence in patients with HCC (P<0.05).
High expression of TNF-α and NF-κB in the HCC microenvironment can predict survival, and patients with high expression have longer survival times and slowing the recurrence time than those in the low-expression group.
在肝细胞癌（HCC）中，炎症因子发挥着重要作用，但其对HCC患者预后的影响仍不太明确。
采用免疫组织化学染色法检测巴塞罗那临床肝癌0 - B期（BCLC - 0 - B）HCC患者肿瘤组织中肿瘤坏死因子-α（TNF-α）和核因子-κB（NF-κB）的表达。通过χ检验分析TNF-α和NF-κB表达与临床病理特征之间的关系。采用Kaplan-Meier分析和对数秩检验比较HCC患者中TNF-α和NF-κB高表达组与低表达组的预后。采用Cox比例风险模型对HCC预后进行单因素和多因素分析。
TNF-α/NF-κB高共表达组的HCC患者生存时间显著更长（P<0.05）。TNF-α和NF-κB高表达是预测HCC患者术后生存和复发的独立预后因素（P<0.05）。
HCC微环境中TNF-α和NF-κB高表达可预测生存，高表达患者比低表达组患者生存时间更长且复发时间延缓。
