Zhang Jun, Shao Weipeng, Zhang Zhenrong, Liu Deruo
Department of Thoracic Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, China.
Transl Cancer Res. 2020 Nov;9(11):6792-6800. doi: 10.21037/tcr-20-2171.
Worldwide, lung cancer has become the most common cancer type and lung cancer gradually becomes the leading cause of cancer death. MiR-146a polymorphism might be associated with the susceptibility to lung cancer. This article will discuss the rate of miR-146 mutation in lung cancer and normal people.
We searched the relevant published literature from January 1, 2009, to December 31, 2019, in English or Chinese, using the PubMed, Medline, Embase, China Biology Medicine disc, China National Knowledge Infrastructure, and WanFang databases. Two reviewers extracted data from eligible studies in duplicate with a standard data collection form and reached a consensus on each item. All analyses were performed using the Review Manager.
In conclusion, the frequency of miR-146a GC genotype mutation in normal people and patients with lung cancer is 44% and 47% respectively and the rate of miR-146a CC genotype mutation in the normal people and patients with lung cancer is 17% and 22% respectively. What's more, the frequency of miR-146a C allele mutation in normal people and patients with lung cancer is 40% and 46% respectively.
In conclusion, we can find that the mutation rate of the lung cancer group is higher than the normal people. In the lung cancer group, we can find that the rate of mutation is highest in Italians and lowest in Indians, both in genotypes and in allele C, in which there are significant differences. Chinese and Koreans have similar mutation rates.
在全球范围内，肺癌已成为最常见的癌症类型，并且肺癌正逐渐成为癌症死亡的主要原因。MiR-146a多态性可能与肺癌易感性相关。本文将探讨肺癌患者和正常人中MiR-146的突变率。
我们检索了2009年1月1日至2019年12月31日期间以英文或中文发表的相关文献，使用了PubMed、Medline、Embase、中国生物医学文献数据库、中国知网和万方数据库。两名审阅者使用标准数据收集表从符合条件的研究中重复提取数据，并就每个项目达成共识。所有分析均使用Review Manager进行。
总之，正常人及肺癌患者中MiR-146a GC基因型突变频率分别为44%和47%，正常人及肺癌患者中MiR-146a CC基因型突变率分别为17%和22%。此外，正常人及肺癌患者中MiR-146a C等位基因突变频率分别为40%和46%。
总之，我们发现肺癌组的突变率高于正常人。在肺癌组中，我们发现无论是基因型还是等位基因C，意大利人的突变率最高，印度人的突变率最低，其中存在显著差异。中国人和韩国人的突变率相似。
