氨茶碱24小时给药的临床及药代动力学问题
Clinical and pharmacokinetic concerns of 24-hour dosing with theophylline.
作者信息
Weinberger M
出版信息
Ann Allergy. 1986 Jan;56(1):2-12.
PMID:3511775
Abstract
Selection of the dosing interval for oral theophylline must consider the product's absorption rate, the patient's elimination rate, and the tolerated fluctuation in serum concentration. Attempts to produce formulations with ultra-slow absorption for "once daily" marketing have thus far resulted in incomplete and erratic absorption.
摘要
口服茶碱给药间隔的选择必须考虑药物的吸收速率、患者的消除速率以及血清浓度可耐受的波动范围。迄今为止，试图研发具有超慢吸收特性以用于“每日一次”销售的制剂，其吸收并不完全且不稳定。
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