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植物合成的金纳米颗粒及其对分离的大鼠半膈肌葡萄糖利用模式的影响。

phytofabricated gold nanoparticles and their impacts on the glucose utilization pattern of the isolated rat hemidiaphragm.

作者信息

Panchamoorthy Rajasekar, Mohan Udayamathi, Muniyan Anbarasan

机构信息

Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai, 602 105, Tamil Nadu, India.

出版信息

Heliyon. 2022 Jan 19;8(1):e08805. doi: 10.1016/j.heliyon.2022.e08805. eCollection 2022 Jan.

DOI:10.1016/j.heliyon.2022.e08805
PMID:35118208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8792090/
Abstract

The integration of nanotechnology with herbal medicines overcomes the limitations of herbal therapy and offers desirable bioactivity. Thus, this study was aimed at synthesizing -gold nanoparticles (AG-AuNPs) and exploring their impact on the glucose utilization pattern of the isolated rat hemidiaphragm. The AG-AuNPs appeared in cherry red color and showed a plasmonic peak at 534nm. The bio-reduced AG-AuNPs appeared as spherical shapes with varying sizes of about 4-15 nm. It also depicted the zeta potential of -19.5 mV, face-centered cubic crystalline nature, stretching vibrations for different functionalities, and stability during various characterization studies. The AG-AuNPs showed non-cytotoxicity and promoted cellular glucose uptake on their exposure to the cell line and the diaphragm, respectively. Moreover, the identified flavonoids and polyphenols of AG depicted interactions with the insulin signaling molecule. The observed results suggest that the interacting ability of AG-AuNPs with the insulin signaling molecule can promote the glucose uptake efficiency of the diaphragm.

摘要

纳米技术与草药的结合克服了草药疗法的局限性，并提供了理想的生物活性。因此，本研究旨在合成金纳米颗粒（AG-AuNPs），并探索其对分离的大鼠半膈肌葡萄糖利用模式的影响。AG-AuNPs呈樱桃红色，在534nm处有一个等离子体峰。生物还原的AG-AuNPs呈球形，大小约为4-15nm不等。它还显示出-19.5mV的zeta电位、面心立方晶体性质、不同官能团的伸缩振动以及在各种表征研究中的稳定性。AG-AuNPs分别在暴露于细胞系和膈肌时显示出无细胞毒性并促进细胞对葡萄糖的摄取。此外，AG中鉴定出的黄酮类化合物和多酚与胰岛素信号分子存在相互作用。观察结果表明，AG-AuNPs与胰岛素信号分子的相互作用能力可以提高膈肌的葡萄糖摄取效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/6bad8108519d/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/08a10e8bd732/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/6a96037fbe4f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/fef5a5c7ed5a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/866820a4090d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/a95f14c7c90e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/afa6946e7d30/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/00987a1c872a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/eb18925bab3f/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/6bad8108519d/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/08a10e8bd732/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/6a96037fbe4f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/fef5a5c7ed5a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/866820a4090d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/a95f14c7c90e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/afa6946e7d30/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/00987a1c872a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/eb18925bab3f/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed58/8792090/6bad8108519d/sc1.jpg

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本文引用的文献

[1]
Optimally biosynthesized, PEGylated gold nanoparticles functionalized with quercetin and camptothecin enhance potential anti-inflammatory, anti-cancer and anti-angiogenic activities.

J Nanobiotechnology. 2021-3-25

[2]
Flavonoids as natural phenolic compounds and their role in therapeutics: an overview.

Futur J Pharm Sci. 2021

[3]
Green synthesis of platinum nanoclusters using lentinan for sensitively colorimetric detection of glucose.

Int J Biol Macromol. 2021-3-1

[4]
A Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle.

Int J Nanomedicine. 2020-12-7

[5]
Current understanding of glucose transporter 4 expression and functional mechanisms.

World J Biol Chem. 2020-11-27

[6]
Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol).

Nat Commun. 2020-11-30

[7]
Green Synthesis of Gold and Silver Nanoparticles by Using Tuber Extract and Evaluation of Their Antibacterial Activity.

Molecules. 2020-10-18

[8]
Phytofabricated silver nanoparticles: Discovery of antibacterial targets against diabetic foot ulcer derived resistant bacterial isolates.

Mater Sci Eng C Mater Biol Appl. 2020-12

[9]
Hesperidin Loaded on Gold Nanoparticles as a Drug Delivery System for a Successful Biocompatible, Anti-Cancer, Anti-Inflammatory and Phagocytosis Inducer Model.

Sci Rep. 2020-6-9

[10]
Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications.

Int J Nanomedicine. 2020-1-16

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