Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Graduate School of Medical Sciences (Research School of Behavioural and Cognitive Neurosciences), University of Groningen, Groningen, the Netherlands.
Transl Vis Sci Technol. 2022 Feb 1;11(2):9. doi: 10.1167/tvst.11.2.9.
To compare retinal oxygen delivery (DO2) and oxygen extraction (VO2) in ophthalmologically healthy subjects with different blood pressure (BP) status.
In this case-control study, we prospectively included 93 eyes of 93 subjects (aged 50-65 years) from a Dutch cohort (n = 167,000) and allocated them to four groups (low BP, normal BP [controls], treated arterial hypertension [AHT], untreated AHT). We estimated vascular calibers from fundus images and fractal dimension from optical coherence tomography angiography scans. We combined calibers, fractal dimension, BP, and intraocular pressure measurements in a proxy of retinal blood flow (RBF), using a Poiseuille-based model. We measured arterial and venous oxygen saturations (SaO2, SvO2) with a scanning laser ophthalmoscope. We calculated the DO2 and VO2 from the RBF, SaO2, and SvO2. We compared the DO2 and VO2 between groups and investigated the DO2-VO2 association.
DO2 and VO2 were different between groups (P = 0.009, P = 0.036, respectively). In a post hoc analysis, the low BP group had lower DO2 than the untreated AHT group (P = 4.9 × 10-4). The low BP group and the treated AHT group had a lower VO2 than the untreated AHT group (P = 0.021 and P = 0.034, respectively). There was a significant DO2-VO2 correlation (Robs = 0.65, bobs = 0.51, P = 2.4 × 10-12). After correcting for shared measurement error, the slope was not significant.
The DO2 and VO2 were altered in ophthalmologically healthy subjects with different BP status. Future studies could elucidate whether these changes can explain the increased risk of ophthalmic pathologies in those subjects.
Understanding the baseline interplay between BP, retinal perfusion, and oxygenation allows for improved evaluation of retinal disease manifestation.
比较不同血压（BP）状态下眼科健康受试者的视网膜氧输送（DO2）和氧摄取（VO2）。
在这项病例对照研究中，我们前瞻性地纳入了来自荷兰队列（n=167000）的 93 名受试者的 93 只眼（年龄 50-65 岁），并将其分为四组（低 BP、正常 BP[对照组]、治疗性动脉高血压[AHT]、未治疗性 AHT）。我们从眼底图像中估计血管口径，并从光相干断层扫描血管造影扫描中估计分形维数。我们使用泊肃叶（Poiseuille）模型将 BP、眼压和血管口径、分形维数测量值结合起来，作为视网膜血流（RBF）的替代物。我们使用扫描激光检眼镜测量动脉和静脉血氧饱和度（SaO2、SvO2）。我们从 RBF、SaO2 和 SvO2 计算 DO2 和 VO2。我们比较了各组之间的 DO2 和 VO2，并研究了 DO2-VO2 的相关性。
各组之间的 DO2 和 VO2 存在差异（P=0.009、P=0.036）。在事后分析中，低 BP 组的 DO2 低于未治疗性 AHT 组（P=4.9×10-4）。低 BP 组和治疗性 AHT 组的 VO2 低于未治疗性 AHT 组（P=0.021 和 P=0.034）。DO2-VO2 存在显著相关性（Robs=0.65、bobs=0.51、P=2.4×10-12）。校正共同测量误差后，斜率无统计学意义。
不同 BP 状态的眼科健康受试者的 DO2 和 VO2 发生改变。未来的研究可以阐明这些变化是否可以解释这些受试者眼部病变风险增加的原因。
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