Woloski B M, Fuller G M, Jamieson J C, Gospodarek E
Biochim Biophys Acta. 1986 Feb 21;885(2):185-91. doi: 10.1016/0167-4889(86)90087-x.
Rat hepatic Gal beta 1----4GlcNAc alpha 2----6 sialyltransferase is released into the blood at elevated levels following an inflammatory challenge: this is a typical response of the group of plasma proteins known as acute-phase reactants. In the present study, primary cultures of liver parenchymal cells are used to demonstrate that the same hepatic cell type that produces plasma proteins such as fibrinogen also produces and releases sialyltransferase. Hepatic production of sialyltransferase is stimulated by a major regulator of hepatic acute-phase reactant production, the hepatocyte-stimulating factor (HSF), while another monokine, interleukin-1, does not affect hepatocyte sialyltransferase production. The maximum increase in sialyltransferase occurs 48 h after exposure to HSF which is considerably later than the fibrinogen response. The sialyltransferase that is stimulated by HSF is the Gal beta 1----4GlcNAc alpha 2----6 isozyme.
炎症刺激后，大鼠肝脏的β-1,4-半乳糖基-N-乙酰葡糖胺α-2,6-唾液酸转移酶会以升高的水平释放到血液中：这是一组被称为急性期反应物的血浆蛋白的典型反应。在本研究中，肝实质细胞原代培养用于证明产生纤维蛋白原等血浆蛋白的同一肝细胞类型也产生并释放唾液酸转移酶。肝脏急性期反应物产生的主要调节因子——肝细胞刺激因子（HSF）可刺激肝脏唾液酸转移酶的产生，而另一种单核因子白细胞介素-1对肝细胞唾液酸转移酶的产生没有影响。唾液酸转移酶的最大增加量出现在暴露于HSF后48小时，这比纤维蛋白原反应要晚得多。受HSF刺激的唾液酸转移酶是β-1,4-半乳糖基-N-乙酰葡糖胺α-2,6同工酶。
