环状 DNA 是癌症的罪魁祸首。
ecDNAs personify cancer gangsters.
机构信息
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
出版信息
Mol Cell. 2022 Feb 3;82(3):500-502. doi: 10.1016/j.molcel.2022.01.003.
Alterations to gene regulatory plexuses typify oncogenesis, and two recent studies from Hung, Yost, Xie et al. (Hung et al., 2021) and Yi et al. (2021) collectively reveal the competitive advantage of extrachromosomal DNAs (ecDNAs) to set their own rules to control transcription by clustering into ecDNA hubs through intermolecular interactions that forge hub-specific regulatory plexuses driving high-oncogene expression.
基因调控网络的改变是肿瘤发生的典型特征，Hung、Yost、Xie 等人的两项最新研究（Hung 等人，2021；Yi 等人，2021）共同揭示了额外染色体 DNA（ecDNA）通过分子间相互作用聚类成 ecDNA 枢纽，从而为自身设定控制转录规则的竞争优势，形成枢纽特异性调控网络，从而驱动高致癌基因表达。
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