癌基因在染色体外 DNA 枢纽中的汇聚。
Oncogene Convergence in Extrachromosomal DNA Hubs.
机构信息
Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California.
Department of Pathology, Stanford University School of Medicine, Stanford, California.
出版信息
Cancer Discov. 2022 May 2;12(5):1195-1198. doi: 10.1158/2159-8290.CD-22-0076.
Abstract
Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs-local congregations of ecDNAs in the nucleus-highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution.
摘要
染色体外 DNA 环（ecDNA）是癌基因扩增的常见机制，与其他类型的癌基因扩增相比，与更差的临床结局相关。ecDNA 枢纽——核内 ecDNA 的局部聚集——的几个最近发现强调了 ecDNA 生物学的独特特征，这些特征可能有助于更高的癌基因表达和肿瘤的快速进化。
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