Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California.
Department of Pathology, Stanford University School of Medicine, Stanford, California.
Cancer Discov. 2022 May 2;12(5):1195-1198. doi: 10.1158/2159-8290.CD-22-0076.
Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs-local congregations of ecDNAs in the nucleus-highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution.
染色体外 DNA 环（ecDNA）是癌基因扩增的常见机制，与其他类型的癌基因扩增相比，与更差的临床结局相关。ecDNA 枢纽——核内 ecDNA 的局部聚集——的几个最近发现强调了 ecDNA 生物学的独特特征，这些特征可能有助于更高的癌基因表达和肿瘤的快速进化。
