Department of Medicine. School of Medicine and Health Sciences, School of Medicine and Health Sciences, Universidad de Oviedo/ISPA, Calle Julián Clavería, s/n, 33006, Oviedo, Spain.
Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid-IdiPaz and CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.
Eur J Nutr. 2022 Aug;61(5):2365-2373. doi: 10.1007/s00394-022-02808-z. Epub 2022 Feb 4.
Magnesium is a profuse intracellular cation with a key role in muscle function and cellular senescence. The aim was to examine the prospective association between 5 year changes in dietary intake of magnesium and changes in physical performance among older men and women.
Prospective study conducted over 863 community-dwellers aged ≥ 65 years from the Seniors-ENRICA cohort (Spain). In 2012 and 2017, a validated computerized face-to-face diet history was used to record the consumption of up to 880 foods. From these data, we estimated changes in dietary magnesium intake. The Short Physical Performance Battery (SPPB) was also conducted in both time points and we obtained changes in the score during follow-up, with positive values indicating physical performance improvement.
Over 5 years of follow-up, an increase in magnesium intake was associated with an increment in the SPPB score among older women [multivariate β (95% confidence interval): 1.01 (0.49; 1.52), p-trend: 0.001]. In addition, changes from non-adherence to adherence to both estimated average requirement and recommended dietary allowance during follow-up period were associated with an increment in SPPB score among older women [1.14 (0.36; 1.92) and 0.84 (0.22; 1.47), respectively]. No significant associations between changes in magnesium intake and changes in SPPB score were observed in men.
Both increase of magnesium intake and change from non-adherence to adherence to dietary reference magnesium intake was prospectively associated with better physical performance among older women, but not among men.
镁是细胞内丰富的阳离子，在肌肉功能和细胞衰老中起着关键作用。本研究旨在探讨 5 年内镁的饮食摄入量变化与老年男性和女性身体机能变化之间的前瞻性关联。
本前瞻性研究对西班牙 Seniors-ENRICA 队列中 863 名年龄≥65 岁的社区居民进行了研究。在 2012 年和 2017 年，采用经过验证的计算机面对面饮食史记录了多达 880 种食物的消费情况。根据这些数据，我们估计了镁的饮食摄入量变化。还在两个时间点进行了简短体能表现电池测试（SPPB），并获得了随访期间的得分变化，正值表示身体机能的提高。
在 5 年的随访期间，镁摄入量的增加与老年女性 SPPB 评分的提高相关（多变量β（95%置信区间）：1.01（0.49；1.52），p 趋势：0.001）。此外，在随访期间，从非依从估计平均需求量到推荐膳食允许量，再到依从估计平均需求量和推荐膳食允许量，与老年女性 SPPB 评分的提高相关[分别为 1.14（0.36；1.92）和 0.84（0.22；1.47）]。在男性中，镁摄入量的变化与 SPPB 评分的变化之间没有显著关联。
镁摄入量的增加以及从非依从估计平均需求量到依从估计平均需求量和推荐膳食允许量的变化，与老年女性的身体机能更好相关，但与男性无关。
