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电针和针刺治疗焦虑症的双盲随机平行临床试验。

Electroacupuncture and acupuncture in the treatment of anxiety - A double blinded randomized parallel clinical trial.

机构信息

Instituto de Medicina Integrativa, Rua Filipe Simões nº19, 3000-186, Coimbra, Portugal; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal.

Escola Superior de Enfermagem de Coimbra & UICISA:E, Avenida Bissaya Barreto Polo A, Apartado 7001, 3046-851, Coimbra, Portugal.

出版信息

Complement Ther Clin Pract. 2022 Feb;46:101541. doi: 10.1016/j.ctcp.2022.101541. Epub 2022 Jan 30.

DOI:10.1016/j.ctcp.2022.101541
PMID:35124475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9760487/
Abstract

BACKGROUND

The estimated number of people living with anxiety disorders worldwide is around 264 million and is estimated to have worsened with the recent pandemic of COVID-19. Acupuncture has shown to have excellent therapeutic effects in reducing anxiety.

DESIGN

Double-blinded randomized controlled clinical trial with 56 participants (21-82 years) with anxiety diagnosed by 3 different anxiety scales (BAI, GAD-7 and OASIS). A 30-min acupuncture session was applied once a week for 10 weeks.

AIMS

Evaluate the effectiveness of acupuncture and electroacupuncture in the treatment of anxiety to verify if: (1) People with high anxiety report reduced scores after 5 and 10 sessions; (2) Salivary cortisol levels accompanied the reduced scores; (3) Electroacupuncture treatment is more effective than acupuncture; (4) the treatments is independent of anxiolytic medication.

METHODS

Volunteers were randomized into 3 groups (control, acupuncture, and electroacupuncture). The results were analyzed by anxiety scales and salivary cortisol tests.

RESULTS

The findings show an improvement in anxiety, assessed by BAI, GAD-7 and OASIS, after the 5th session of acupuncture (p < 0.05) and electroacupuncture (p < 0.05) and the 10th session for both techniques (p < 0.001). The salivary cortisol values measured in the morning followed this pattern (p < 0.05), although the reduction of the night cortisol values was not statistically significant. Electroacupuncture and acupuncture show similar efficacy. The positive effect after the treatments is independent of anxiolytic medication (p < 0.001).

CONCLUSION

Acupuncture and electroacupuncture are effective in treating anxiety on their own or as adjuncts to pharmacological therapy.

TRIAL REGISTRATION NUMBER

NºP445-08/2017 (Unidade de Investigação em Ciências da Saúde).

摘要

背景

全球范围内,患有焦虑症的人数估计约为 2.64 亿,且由于近期 COVID-19 大流行,该数字预计有所恶化。针灸在降低焦虑方面显示出极好的治疗效果。

设计

这是一项双盲随机对照临床试验,共纳入 56 名(年龄 21-82 岁)焦虑症患者(通过 BAI、GAD-7 和 OASIS 三种不同的焦虑量表诊断)。每周进行一次 30 分钟的针灸治疗,共进行 10 周。

目的

评估针灸和电针对治疗焦虑的有效性,以验证以下假设:(1)高焦虑人群在 5 次和 10 次治疗后评分降低;(2)唾液皮质醇水平随评分降低而降低;(3)电针对治疗更有效;(4)治疗与抗焦虑药物无关。

方法

志愿者被随机分为 3 组(对照组、针灸组和电针组)。通过焦虑量表和唾液皮质醇测试对结果进行分析。

结果

结果显示,针灸和电针治疗 5 次(p<0.05)和 10 次(p<0.001)后,BAI、GAD-7 和 OASIS 评估的焦虑均得到改善。皮质醇水平也呈现出类似的模式(p<0.05),尽管夜间皮质醇值的降低无统计学意义。电针和针灸的疗效相似。治疗后的积极效果与抗焦虑药物无关(p<0.001)。

结论

针灸和电针单独或作为药物治疗的辅助手段对焦虑症均有效。

试验注册号

NºP445-08/2017(健康科学研究单位)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/9760487/e07704e79827/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/9760487/3ba1a6a96a76/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/9760487/e4f72e4629ce/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/9760487/e07704e79827/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/9760487/3ba1a6a96a76/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/9760487/e4f72e4629ce/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f26/9760487/e07704e79827/gr2_lrg.jpg

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