Guey Baptiste, Ablasser Andrea
Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.
Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.
Curr Opin Immunol. 2022 Feb;74:164-171. doi: 10.1016/j.coi.2022.01.004. Epub 2022 Feb 3.
The recognition of DNA through the cGAS-STING pathway plays a critical role in antiviral immunity, but can also drive maladaptive immune responses underlying several pathological conditions. Despite its importance, understanding the organization of cGAS-STING signaling axis in the 3D space of a cell is relatively limited. In this review, we discuss recent progress in understanding the spatial coordination of DNA-induced cGAS-STING activity and its relevance in balancing innate immune responses toward (self-) DNA. We also consider the importance of context-specific co-factors and end by suggesting interesting areas for further research into spatial aspects of DNA-induced innate immunity.
通过cGAS-STING途径识别DNA在抗病毒免疫中起着关键作用，但也会驱动几种病理状况下的适应性免疫反应。尽管其很重要，但对cGAS-STING信号轴在细胞三维空间中的组织方式的了解相对有限。在这篇综述中，我们讨论了在理解DNA诱导的cGAS-STING活性的空间协调及其在平衡针对（自身）DNA的固有免疫反应中的相关性方面的最新进展。我们还考虑了特定背景辅助因子的重要性，并最后提出了关于DNA诱导的固有免疫空间方面进一步研究的有趣领域。
