• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

膳食蛋白质在肠道葡萄糖吸收调节中作用的探索性研究

An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption.

作者信息

Dugardin Camille, Fleury Léa, Touche Véronique, Ahdach Farah, Lesage Jean, Tenenbaum Mathie, Everaert Nadia, Briand Olivier, Lestavel Sophie, Ravallec Rozenn, Cudennec Benoit

机构信息

Univ. Lille, Univ. Artois, Université de Liège, UMRT 1158 BioEcoAgro - Bénéfice santé d'hydrolysats de protéines et coproduits agro-alimentaires, Lille, France.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, Lille, France.

出版信息

Front Nutr. 2022 Jan 19;8:769773. doi: 10.3389/fnut.2021.769773. eCollection 2021.

DOI:10.3389/fnut.2021.769773
PMID:35127780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8808719/
Abstract

Several studies have demonstrated that high protein diets improve glucose homeostasis. Nevertheless, the mechanisms underlying this effect remain elusive. This exploratory study aims to screen and compare the acute effects of dietary proteins from different sources on intestinal glucose absorption. Six dietary proteins from various sources were thus selected and digested thanks to the INFOGEST static gastrointestinal digestion protocol. The digested proteins were able to decrease intestinal glucose absorption and . Moreover, acute ingestion of casein and fish gelatin led to improved glucose tolerance in Wistar rats without significant effect on insulin secretion. In parallel, GLUT2 mRNA expression in enterocytes was decreased following short-term incubation with some of the digested proteins. These results strengthen the evidence that digested protein-derived peptides and amino acids are key regulators of glucose homeostasis and highlight their role in intestinal glucose absorption.

摘要

多项研究表明，高蛋白饮食可改善葡萄糖稳态。然而，这种作用背后的机制仍不清楚。这项探索性研究旨在筛选和比较不同来源的膳食蛋白质对肠道葡萄糖吸收的急性影响。因此，根据INFOGEST静态胃肠消化方案选择并消化了六种不同来源的膳食蛋白质。消化后的蛋白质能够降低肠道葡萄糖吸收。此外，急性摄入酪蛋白和鱼明胶可改善Wistar大鼠的葡萄糖耐量，而对胰岛素分泌无显著影响。同时，用一些消化后的蛋白质进行短期孵育后，肠细胞中GLUT2 mRNA表达降低。这些结果进一步证明，消化后的蛋白质衍生肽和氨基酸是葡萄糖稳态的关键调节因子，并突出了它们在肠道葡萄糖吸收中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c40/8808719/5f0997534ed0/fnut-08-769773-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c40/8808719/e9a0bbcec823/fnut-08-769773-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c40/8808719/b2e5d64b4221/fnut-08-769773-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c40/8808719/b831d84f2ec9/fnut-08-769773-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c40/8808719/5f0997534ed0/fnut-08-769773-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c40/8808719/e9a0bbcec823/fnut-08-769773-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c40/8808719/b2e5d64b4221/fnut-08-769773-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c40/8808719/b831d84f2ec9/fnut-08-769773-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c40/8808719/5f0997534ed0/fnut-08-769773-g0004.jpg

相似文献

1
An Exploratory Study of the Role of Dietary Proteins in the Regulation of Intestinal Glucose Absorption.膳食蛋白质在肠道葡萄糖吸收调节中作用的探索性研究
Front Nutr. 2022 Jan 19;8:769773. doi: 10.3389/fnut.2021.769773. eCollection 2021.
2
Expression of Na+/glucose co-transporter 1 (SGLT1) in the intestine of piglets weaned to different concentrations of dietary carbohydrate.仔猪断奶后不同饲粮碳水化合物浓度下肠道钠-葡萄糖协同转运蛋白 1（SGLT1）的表达。
Br J Nutr. 2010 Sep;104(5):647-55. doi: 10.1017/S0007114510000954. Epub 2010 Apr 13.
3
Effects of dietary glucose and sodium chloride on intestinal glucose absorption of common carp (Cyprinus carpio L.).日粮葡萄糖和氯化钠对鲤鱼（Cyprinus carpio L.）肠道葡萄糖吸收的影响。
Biochem Biophys Res Commun. 2018 Jan 8;495(2):1948-1955. doi: 10.1016/j.bbrc.2017.12.065. Epub 2017 Dec 13.
4
The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing.SGLT1 和 GLUT2 在肠道葡萄糖转运和感应中的作用。
PLoS One. 2014 Feb 26;9(2):e89977. doi: 10.1371/journal.pone.0089977. eCollection 2014.
5
Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice.单糖膳食作用于肠上皮细胞顶端膜上的葡萄糖转运蛋白2（GLUT2）以改善糖吸收：一项在GLUT2基因敲除小鼠中的研究
J Physiol. 2003 Nov 1;552(Pt 3):823-32. doi: 10.1113/jphysiol.2003.049247. Epub 2003 Aug 22.
6
Molecular characterisation of carbohydrate digestion and absorption in equine small intestine.马属动物小肠碳水化合物消化与吸收的分子特征
Equine Vet J. 2002 Jul;34(4):349-58. doi: 10.2746/042516402776249209.
7
Specific Lactobacillus probiotic strains decrease transepithelial glucose transport through GLUT2 downregulation in intestinal epithelial cell models.特定的乳杆菌益生菌菌株通过下调肠道上皮细胞模型中的 GLUT2 来降低跨上皮葡萄糖转运。
Nutr Res. 2021 Feb;86:10-22. doi: 10.1016/j.nutres.2020.11.008. Epub 2020 Nov 20.
8
Regulation of Intestinal Glucose Absorption by Ion Channels and Transporters.离子通道和转运体对肠道葡萄糖吸收的调节
Nutrients. 2016 Jan 14;8(1):43. doi: 10.3390/nu8010043.
9
GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice.肠上皮细胞顶膜和细胞内膜中 GLUT2 的积累：肥胖症人类受试者和 ob/ob 及高脂喂养小鼠的研究。
Diabetes. 2011 Oct;60(10):2598-607. doi: 10.2337/db10-1740. Epub 2011 Aug 18.
10
Intestinal Glucose Absorption Was Reduced by Vertical Sleeve Gastrectomy via Decreased Gastric Leptin Secretion.垂直袖状胃切除术通过减少胃泌素分泌来降低肠道葡萄糖吸收。
Obes Surg. 2018 Dec;28(12):3851-3861. doi: 10.1007/s11695-018-3351-4.

引用本文的文献

1
A Specific Collagen Hydrolysate Improves Postprandial Glucose Tolerance in Normoglycemic and Prediabetic Mice and in a First Proof of Concept Study in Healthy, Normoglycemic and Prediabetic Humans.一种特定的胶原蛋白水解物可改善血糖正常和糖尿病前期小鼠的餐后葡萄糖耐量，并在一项针对健康、血糖正常和糖尿病前期人群的首次概念验证研究中得到证实。
Food Sci Nutr. 2024 Oct 20;12(11):9607-9620. doi: 10.1002/fsn3.4538. eCollection 2024 Nov.
2
Protein hydrolysates of seed: Antioxidant and antihyperglycaemic potential as ingredient for the management of type-2 diabetes.种子蛋白水解物：作为2型糖尿病管理成分的抗氧化和降血糖潜力。
Heliyon. 2024 Mar 21;10(7):e28368. doi: 10.1016/j.heliyon.2024.e28368. eCollection 2024 Apr 15.
3

本文引用的文献

1
The metabolic impact of small intestinal nutrient sensing.小肠营养感应的代谢影响。
Nat Commun. 2021 Feb 10;12(1):903. doi: 10.1038/s41467-021-21235-y.
2
Explorative Screening of Bioactivities Generated by Plant-Based Proteins after In Vitro Static Gastrointestinal Digestion.基于植物蛋白的生物活性经体外静态胃肠道消化后的探索性筛选。
Nutrients. 2020 Dec 5;12(12):3746. doi: 10.3390/nu12123746.
3
In Vitro Assessment of the Impact of Industrial Processes on the Gastrointestinal Digestion of Milk Protein Matrices Using the INFOGEST Protocol.
In Vivo and In Vitro Comparison of the DPP-IV Inhibitory Potential of Food Proteins from Different Origins after Gastrointestinal Digestion.
不同来源的食物蛋白经胃肠道消化后 DPP-IV 抑制潜力的体内和体外比较。
Int J Mol Sci. 2022 Jul 28;23(15):8365. doi: 10.3390/ijms23158365.
4
Evolution of the diagnostic value of "the sugar of the blood": hitting the sweet spot to identify alterations in glucose dynamics.血糖的诊断价值演变：直击关键，识别葡萄糖动态变化。
Physiol Rev. 2023 Jan 1;103(1):7-30. doi: 10.1152/physrev.00015.2022. Epub 2022 May 30.
使用INFOGEST方案对工业加工过程对乳蛋白基质胃肠道消化的影响进行体外评估。
Foods. 2020 Oct 30;9(11):1580. doi: 10.3390/foods9111580.
4
Intestinal Fructose and Glucose Metabolism in Health and Disease.肠道果糖和葡萄糖代谢在健康和疾病中的作用。
Nutrients. 2019 Dec 29;12(1):94. doi: 10.3390/nu12010094.
5
Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport.二甲双胍通过抑制肠道葡萄糖转运来急性降低血糖水平。
Sci Rep. 2019 Apr 16;9(1):6156. doi: 10.1038/s41598-019-42531-0.
6
INFOGEST static in vitro simulation of gastrointestinal food digestion.INFOGEST 静态体外模拟胃肠道食物消化。
Nat Protoc. 2019 Apr;14(4):991-1014. doi: 10.1038/s41596-018-0119-1. Epub 2019 Mar 18.
7
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial.鳕鱼蛋白水解物对健康受试者餐后葡萄糖代谢的影响：一项双盲交叉试验。
J Nutr Sci. 2018 Nov 28;7:e33. doi: 10.1017/jns.2018.23. eCollection 2018.
8
Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities.食物来源的生物活性肽在人类健康中的挑战和机遇
Nutrients. 2018 Nov 12;10(11):1738. doi: 10.3390/nu10111738.
9
High-protein diets for weight management: Interactions with the intestinal microbiota and consequences for gut health. A position paper by the my new gut study group.高蛋白饮食用于体重管理：与肠道微生物群的相互作用及其对肠道健康的影响。由我的新肠道研究小组发布的立场文件。
Clin Nutr. 2019 Jun;38(3):1012-1022. doi: 10.1016/j.clnu.2018.09.016. Epub 2018 Sep 20.
10
Dietary Protein and Energy Balance in Relation to Obesity and Co-morbidities.与肥胖及合并症相关的膳食蛋白质与能量平衡
Front Endocrinol (Lausanne). 2018 Aug 6;9:443. doi: 10.3389/fendo.2018.00443. eCollection 2018.