National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Department of Chemistry, Institute of Biomimetic Materials, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, China.
Adv Mater. 2022 May;34(20):e2200115. doi: 10.1002/adma.202200115. Epub 2022 Apr 14.
Due to the wet and dynamic environment of the oral cavity, the healing of intraoral wounds, such as tooth extraction wounds, requires stable and firm wound dressings. In clinical practice, cotton balls and gauzes, sponge plugs, or sutures are used to treat extraction wounds, but none of these means can continuously isolate the wound from the intraoral environment and facilitate ideal healing conditions. Herein, inspired by the natural extracellular matrix, a family of wound dressings is developed for intraoral wound repair. Infiltrating a ductile long-chain hydrogel network into a prefabricated, sturdy macromolecular meshwork and in situ crosslinking endowed the composite hydrogel with controllable swelling behaviors and robust mechanical properties. The macromolecular meshwork functioned as the backbone to support the composite and restricts the swelling of the long-chain hydrogel network. In vitro tests verified that this wound dressing can provide durable protection for intraoral wounds against complex irritations. Furthermore, accelerated wound healing occurred when the wound dressing is applied in vivo on a canine tooth extraction model, due to the effective reduction of acute inflammation. These results suggest that this family of bioinspired hydrogels has great potential for application as intraoral wound dressing.
由于口腔内环境潮湿且动态变化，牙内创伤（如拔牙创口）的愈合需要稳定且坚固的创伤敷料。在临床实践中，通常使用棉花球和纱布、海绵塞或缝线来处理拔牙创口，但这些方法都不能持续将创口与口腔环境隔离开来，从而难以创造理想的愈合条件。受天然细胞外基质的启发，人们开发了一系列用于口腔内创伤修复的创伤敷料。将柔韧的长链水凝胶网络渗透到预制的坚固高分子网格中，并进行原位交联，使复合水凝胶具有可控制的溶胀行为和强大的机械性能。高分子网格作为支撑物发挥作用，支撑复合材料并限制长链水凝胶网络的溶胀。体外测试验证了这种创伤敷料能够为口腔内创伤提供持久的保护，防止其受到复杂刺激。此外，当该创伤敷料应用于犬牙拔牙模型的体内时，由于急性炎症的有效减轻，加速了创伤愈合。这些结果表明，这种仿生水凝胶具有作为口腔内创伤敷料的巨大应用潜力。
