Jiangsu Agri-Animal Husbandry Vocational College, Taizhou, 225300 Jiangsu, China.
Nanjing Agricultural University, Nanjing, 210095 Jiangsu, China.
Comput Math Methods Med. 2022 Jan 29;2022:8660752. doi: 10.1155/2022/8660752. eCollection 2022.
Swine pneumonia commonly known as swine pasteurellosis is an infectious disease of swine caused by Pasteurella multocida infection. It has been reported that Toll-like receptors (TLRs) play a vital role in swine pneumonia progression. However, the underlying mechanism has not been elucidated. This research was aimed at investigating the molecular mechanism by which TLR9 regulates swine pneumonia progression. Our findings illustrated that the HD-13 strain of Pasteurella multocida D (HD-13) accelerated TLR9 expression in porcine alveolar macrophage 3D4/21 cells; HD-13 activated the inflammatory response via accelerating TLR9 expression. Mechanistically, HD-13 activated mitogen-activated protein kinase (MAPK) and nuclear factor kB (NF-B) signals. In conclusion, HD-13 may activate MAPK and NF-B pathways via accelerating TLR9 expression, thereby accelerating the inflammatory response in the progression of swine pneumonia. TLR9 may serve as a novel therapeutic target for swine pneumonia. Our research may provide a theoretical basis for the prevention and treatment of swine pneumonia.
猪肺炎通常被称为猪巴氏杆菌病，是由多杀性巴氏杆菌感染引起的猪传染病。有报道称，Toll 样受体（TLR）在猪肺炎的进展中起着至关重要的作用。然而，其潜在的机制尚未阐明。本研究旨在探讨 TLR9 调控猪肺炎进展的分子机制。我们的研究结果表明，多杀性巴氏杆菌 D 型的 HD-13 株（HD-13）加速了猪肺泡巨噬细胞 3D4/21 细胞中 TLR9 的表达；HD-13 通过加速 TLR9 表达激活了炎症反应。从机制上讲，HD-13 激活了丝裂原活化蛋白激酶（MAPK）和核因子 kB（NF-B）信号。综上所述，HD-13 可能通过加速 TLR9 表达激活 MAPK 和 NF-B 通路，从而加速猪肺炎进展中的炎症反应。TLR9 可能成为猪肺炎的一个新的治疗靶点。本研究可为猪肺炎的防治提供理论依据。
