Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy.
Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Via Massarenti n.9, 40138, Bologna, Italy.
Langenbecks Arch Surg. 2022 Jun;407(4):1499-1506. doi: 10.1007/s00423-021-02427-y. Epub 2022 Feb 7.
Recent studies have reported worse outcomes of converted laparoscopic distal pancreatectomy (CLDP) with respect to total laparoscopic (TLDP) and open (ODP). The aim of the study was to evaluate the impact of conversion on patient outcome and on total cost.
Patients requiring a conversion (CLDP) were compared with both TLDP and ODP patients. The relevant patient- and tumour-related variables were collected for each patient. Both intra and postoperative data were extracted. Propensity score matching (PSM) analysis was carried out to equate the groups compared.
Two hundred and five patients underwent DP, 105 (51.2%) ODPs, 81 (39.5%) TLDPs, and 19 (9.3%) CLDPs. After PSM, 19 CLDPs, 38 TLDPs, and 38 ODPs were compared. Patients who underwent CLDP showed a significantly longer operative time (P < 0.001), and an increase in blood loss (P = 0.032) and total cost (P = 0.034) with respect to TLDP, and a significantly longer operative time (P < 0.001), less frequent postoperative morbidity (P = 0.050), and a higher readmission rate (P = 0.035) with respect to ODP.
Total laparoscopic pancreatectomy was superior regarding operative findings and total costs with respect to CLDP; ODP showed a higher postoperative morbidity rate and a lower readmission rate with respect to CLDP. However, the reasons for the readmission of patients who underwent CLDP were mainly related to postoperative pancreatic fistula (POPF) grade B which is usually due to pancreas texture. Thus, the majority of distal pancreatectomies can be started using a minimally invasive approach, performing an early conversion if necessary.
最近的研究报告显示,与完全腹腔镜(TLDP)和开放(ODP)相比,转化后的腹腔镜胰体尾切除术(CLDP)的结局更差。本研究旨在评估转化对患者结局和总费用的影响。
将需要转化的患者(CLDP)与 TLDP 和 ODP 患者进行比较。收集每位患者的相关患者和肿瘤相关变量。提取术中及术后数据。进行倾向评分匹配(PSM)分析以均衡比较组。
205 例患者行 DP,其中 105 例(51.2%)为 ODP,81 例(39.5%)为 TLDP,19 例(9.3%)为 CLDP。PSM 后,19 例 CLDP、38 例 TLDP 和 38 例 ODP 进行比较。与 TLDP 相比,行 CLDP 的患者手术时间明显延长(P<0.001),术中出血量增加(P=0.032),总费用增加(P=0.034),与 ODP 相比,手术时间明显延长(P<0.001),术后并发症发生率较低(P=0.050),再入院率较高(P=0.035)。
与 CLDP 相比,TLDP 在手术结果和总费用方面具有优势;与 CLDP 相比,ODP 的术后并发症发生率较高,再入院率较低。然而,行 CLDP 的患者再入院的主要原因是术后胰瘘(POPF)分级 B,这通常与胰腺质地有关。因此,大多数胰体尾切除术可以采用微创方式开始,如果需要,可以尽早进行转化。