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Patients with moderate to severe COVID-19 have an impaired cytokine response with an exhausted and senescent immune phenotype.

作者信息

Dhanda Ashwin D, Felmlee Dan, Boeira Paula, Moodley Prebashan, Tan Huey, Scalioni Leticia De Paula, Lilly Kristen, Sheridan David A, Cramp Matthew E

机构信息

South West Liver Unit, University Hospitals Plymouth NHS Trust, Plymouth, UK; Hepatology Research Group, Faculty of Health, University of Plymouth, Plymouth, UK.

Hepatology Research Group, Faculty of Health, University of Plymouth, Plymouth, UK.

出版信息

Immunobiology. 2022 Mar;227(2):152185. doi: 10.1016/j.imbio.2022.152185. Epub 2022 Feb 4.

DOI:10.1016/j.imbio.2022.152185
PMID:35134628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8813783/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9697/8813783/9c7fea04c27c/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9697/8813783/9c7fea04c27c/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9697/8813783/9c7fea04c27c/gr1_lrg.jpg

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J Infect Dis. 2021 Nov 22;224(10):1672-1683. doi: 10.1093/infdis/jiab425.
2
In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods.常用消毒产品和方法对 SARS-CoV-2 的体外灭活作用。
Sci Rep. 2021 Jan 28;11(1):2418. doi: 10.1038/s41598-021-82148-w.
3
The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome.
严重 COVID-19 肺炎中失调的固有免疫反应可能导致更差的结果。
J Transl Med. 2020 Dec 3;18(1):457. doi: 10.1186/s12967-020-02646-9.
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Cellular senescence as a potential mediator of COVID-19 severity in the elderly.细胞衰老作为老年人 COVID-19 严重程度的潜在介导者。
Aging Cell. 2020 Oct;19(10):e13237. doi: 10.1111/acel.13237. Epub 2020 Sep 21.
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Science. 2020 Sep 4;369(6508). doi: 10.1126/science.abc8511. Epub 2020 Jul 15.
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