Murphy W M, Dean P J, Brasfield J A, Tatum L
Am J Surg Pathol. 1986 Mar;10(3):170-4. doi: 10.1097/00000478-198603000-00003.
A prospective study of 386 consecutive transurethral prostatic resections from 383 patients with clinically benign glands was undertaken to determine the optimal sampling of chips required for the histologic detection of all clinically significant prostatic carcinomas. Cancers were graded according to two systems and staged by counting involved chips as well as estimating volume density. All Stage A2 prostatic carcinomas were detected by histologic examination of 6 g of randomly selected chips. Although additional tumors were detected in direct proportion to the amount of tissue examined, they were small, well-differentiated, Stage A1 lesions. Histologic sampling of 12 g of randomly selected prostatic chips detected almost 90% of incidental carcinomas, including all clinically significant neoplasms.
对383例临床诊断为良性腺体的患者连续进行386例经尿道前列腺切除术进行前瞻性研究，以确定组织学检测所有临床显著前列腺癌所需的最佳切片取样量。根据两种系统对癌症进行分级，并通过计算受累切片数量以及估计体积密度来分期。通过对6克随机选择的切片进行组织学检查，检测到了所有A2期前列腺癌。虽然检测到的额外肿瘤与检查的组织量成正比，但它们都是小的、高分化的A1期病变。对12克随机选择的前列腺切片进行组织学取样，检测到了近90%的偶然癌，包括所有临床显著的肿瘤。
