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新型冠状病毒肺炎阳性患者的临床特征与转归——一项横断面研究

Clinical profile and outcomes of COVID-19 positive patients -A cross sectional study.

作者信息

Karthaka Christina, Baliga Sulakshana S, Walvekar Padmaja R

机构信息

Department of Community Medicine, J.N. Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

出版信息

J Family Med Prim Care. 2021 Nov;10(11):4036-4040. doi: 10.4103/jfmpc.jfmpc_301_21. Epub 2021 Nov 29.

Abstract

BACKGROUND

Globally 220 countries and territories are affected and cases of COVID-19 have increased by 8% resulting in 3.6 million new cases. The most common symptoms include fever, cough, loss of taste or smell, headache and mortality rate was uncertain. The objective of this study is to know the clinical profile and outcomes of COVID-19 positive patients.

METHODOLOGY

A Cross-Sectional Study was conducted for 2 months (October-December 2020) among 727 COVID 19 positive patients residing in the field practice area of 4 health centers. Details regarding medical history, exposure history, underlying co-morbidities, symptoms, signs clinical features and outcomes (i.e, cured, mortality, and length of stay) were obtained.

RESULTS

The mean age of participants was 41 ± 17 years, 59.28% were males, 40.71% were females. A significant association was found between age, family history of disease, co-morbid disease, medication history, smoking habit, alcohol consumption, type of symptoms, isolation type, treatment given with outcomes ( < 0.05). Subjects with previous history of medication (HR, 2.749; 95% CI 1.0774-7.015), and those who had symptoms (HR, 3.6446; 95% CI1.0280-12.921) were associated with increased risk of death as compared to others.

CONCLUSION

COVID-19 positive was found in 56% of patients, they were less severe and improved with medication and deaths were found in 3.85% of patients. Fever was noted in only 15.72% of patients, gastrointestinal symptoms in 1.22% and respiratory symptoms in 14.74% of patients. Participants with older age were significantly associated with complications and those with co-morbidities were significantly associated with death on multinominal logistic analysis.

摘要

背景

全球220个国家和地区受到影响,新冠病毒病病例增加了8%,新增病例达360万例。最常见的症状包括发热、咳嗽、味觉或嗅觉丧失、头痛,死亡率尚不确定。本研究的目的是了解新冠病毒病阳性患者的临床特征和转归。

方法

对居住在4个健康中心实地诊疗区域的727例新冠病毒病阳性患者进行了为期2个月(2020年10月至12月)的横断面研究。获取了有关病史、接触史、潜在合并症、症状、体征、临床特征和转归(即治愈、死亡和住院时间)的详细信息。

结果

参与者的平均年龄为41±17岁,男性占59.28%,女性占40.71%。在年龄、家族病史、合并疾病、用药史、吸烟习惯、饮酒情况、症状类型、隔离类型、治疗与转归之间发现了显著关联(P<0.05)。与其他患者相比,有用药史的受试者(风险比,2.749;95%置信区间1.0774 - 7.015)以及有症状的受试者(风险比,3.6446;95%置信区间1.0280 - 12.921)死亡风险增加。

结论

56%的患者新冠病毒病呈阳性,病情较轻,经药物治疗后好转,3.85%的患者死亡。仅15.72%的患者出现发热,1.22%的患者出现胃肠道症状,14.74%的患者出现呼吸道症状。在多项逻辑分析中,年龄较大的参与者与并发症显著相关,合并症患者与死亡显著相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb11/8797092/6d02718e6b46/JFMPC-10-4036-g001.jpg

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