• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

针对英国 65 岁健康人群的偶发性心房颤动和房颤相关卒中进行目标人群筛查与全人群筛查的成本比较。

Targeted vs. full population screening costs for incident atrial fibrillation and AF-related stroke for a healthy population aged 65 years in the United Kingdom.

机构信息

Liverpool Centre for Cardiovascular Science, University of Liverpool, L7 8TX, United Kingdom.

出版信息

Eur Heart J Qual Care Clin Outcomes. 2022 Nov 17;8(8):892-898. doi: 10.1093/ehjqcco/qcac005.

DOI:10.1093/ehjqcco/qcac005
PMID:35138372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9670327/
Abstract

AIMS

Atrial Fibrillation (AF) is the most common sustained heart arrhythmia and a major preventable cause of stroke. Stroke accounts for a large amount of health and social care funding and over the coming years is likely to place an increasing cost burden on the wider UK health care system. We therefore need to understand how an opportunistic AF screening programme would impact on healthcare costs of AF (and AF-related stroke) for the NHS.

METHODS AND RESULTS

Using UK population forecasts and prior published data we initially calculated the number of people to be screened, newly-diagnosed and treated for Atrial Fibrillation (AF), and the associated costs of such a programme for all 65 year olds and for just a 'high risk' group. The reduction in the number of stroke cases recorded and the associated cost savings were subsequently calculated, for 2020 and the projected estimates over the following decade. The number of newly diagnosed AF patients at 65 years old for the two groups (all 65 year olds and for just a 'high risk' group) would be in 6754 and 797 in 2020, rising to 9200 and 1086 in 2030, respectively. In 2020 the cost of the screening programme for the two options would be £14.3m and £1.7m. If AF is medicated and monitored then there would be a subsequent reduction in the number of stroke cases in 2020 by 4323 or 510 depending on the group screened, with associated savings of £394.2m and £46.5m,  respectively. Focussing on 2030 and should opportunistic screenings for AF be introduced at age 65, with subsequent treatment, it is predicted to reduce the number of stroke cases over the decade by 5888 if all 65 year olds are screened and 695 if just the high risk group are screened. If the number of strokes can be reduced by treating these screened AF patients, we would substantially reduce the health and social care costs of stroke by £654.6m and £77.3m,  respectively.

CONCLUSION

The number of newly diagnosed AF patients at age 65 will rise over the decade between 2020 and 2030. Screening and treatment of AF will substantially reduce the health and social care costs of AF-related stroke in the NHS.

摘要

目的

心房颤动(AF)是最常见的持续性心律失常,也是中风的主要可预防原因。中风占大量的医疗保健支出,在未来几年内,它可能会给英国更广泛的医疗保健系统带来越来越大的成本负担。因此,我们需要了解机会性房颤筛查计划如何影响 NHS 房颤(和房颤相关中风)的医疗成本。

方法和结果

使用英国人口预测和之前发表的数据,我们最初计算了筛查、新诊断和治疗房颤的人数,以及为所有 65 岁及仅高危人群进行此类计划的相关成本。随后计算了 2020 年及未来十年记录的中风病例数量减少和相关成本节约。对于两个组(所有 65 岁及仅高危人群),2020 年新诊断的房颤患者人数将分别为 6754 人和 797 人,到 2030 年将分别上升至 9200 人和 1086 人。2020 年,这两种选择的筛查计划成本分别为 1430 万英镑和 170 万英镑。如果对房颤进行药物治疗和监测,那么 2020 年筛查组中风病例数量将分别减少 4323 例或 510 例,分别节省 3.942 亿英镑和 4650 万英镑。如果在 2030 年左右,如果在 65 岁时对房颤进行机会性筛查,并进行后续治疗,可以预测,如果对所有 65 岁人群进行筛查,这十年中风病例数将减少 5888 例,如果仅对高危人群进行筛查,将减少 695 例。如果通过治疗这些筛查的房颤患者可以减少中风病例,我们将分别减少 NHS 中风相关房颤的健康和社会保健成本 6.546 亿英镑和 7730 万英镑。

结论

到 2030 年,65 岁新诊断的房颤患者人数将在 2020 年至 2030 年的十年间上升。房颤的筛查和治疗将大大降低 NHS 房颤相关中风的健康和社会保健成本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/8b3d1b7a4759/qcac005fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/3f8f48ca5504/qcac005fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/d4b6c104c18c/qcac005fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/59a7742d5b22/qcac005fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/f82ee07c42fb/qcac005fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/8b3d1b7a4759/qcac005fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/3f8f48ca5504/qcac005fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/d4b6c104c18c/qcac005fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/59a7742d5b22/qcac005fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/f82ee07c42fb/qcac005fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ab6/9670327/8b3d1b7a4759/qcac005fig5.jpg

相似文献

1
Targeted vs. full population screening costs for incident atrial fibrillation and AF-related stroke for a healthy population aged 65 years in the United Kingdom.针对英国 65 岁健康人群的偶发性心房颤动和房颤相关卒中进行目标人群筛查与全人群筛查的成本比较。
Eur Heart J Qual Care Clin Outcomes. 2022 Nov 17;8(8):892-898. doi: 10.1093/ehjqcco/qcac005.
2
Atrial fibrillation in the UK: predicting costs of an emerging epidemic recognizing and forecasting the cost drivers of atrial fibrillation-related costs.英国的心房颤动:预测这一新兴流行病的成本 认识和预测与心房颤动相关成本的成本驱动因素。
Eur Heart J Qual Care Clin Outcomes. 2022 Mar 2;8(2):187-194. doi: 10.1093/ehjqcco/qcaa093.
3
A randomised controlled trial and cost-effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in people aged 65 and over. The SAFE study.一项针对65岁及以上人群检测心房颤动的系统筛查(针对性筛查和全人群筛查)与常规做法的随机对照试验及成本效益研究。SAFE研究。
Health Technol Assess. 2005 Oct;9(40):iii-iv, ix-x, 1-74. doi: 10.3310/hta9400.
4
Echocardiography in newly diagnosed atrial fibrillation patients: a systematic review and economic evaluation.新发心房颤动患者的超声心动图:系统评价和经济评估。
Health Technol Assess. 2013 Aug;17(36):1-263, v-vi. doi: 10.3310/hta17360.
5
Age-specific incidence, outcome, cost, and projected future burden of atrial fibrillation-related embolic vascular events: a population-based study.特定年龄的心房颤动相关栓塞性血管事件的发病率、结局、成本及预计未来负担:一项基于人群的研究。
Circulation. 2014 Oct 7;130(15):1236-44. doi: 10.1161/CIRCULATIONAHA.114.010942. Epub 2014 Sep 10.
6
Cost-effectiveness of screening for atrial fibrillation in primary care with a handheld, single-lead electrocardiogram device in the Netherlands.荷兰基层医疗中使用手持式单导联心电图设备筛查心房颤动的成本效益分析。
Europace. 2018 Jan 1;20(1):12-18. doi: 10.1093/europace/euw285.
7
Estimating the impact of implementing an integrated care management approach with Atrial fibrillation Better Care (ABC) pathway for patients with atrial fibrillation in England from 2020 to 2040.估计 2020 年至 2040 年在英格兰实施房颤综合护理管理方法(Atrial fibrillation Better Care [ABC] 路径)对房颤患者的影响。
Eur Heart J Qual Care Clin Outcomes. 2024 Jun 20;10(4):326-333. doi: 10.1093/ehjqcco/qcad055.
8
The cost savings of newer oral anticoagulants in atrial fibrillation-related stroke prevention
.新型口服抗凝药在预防心房颤动相关卒中方面的成本节约
Int J Clin Pharmacol Ther. 2017 Mar;55(3):220-230. doi: 10.5414/CP202651.
9
Feasibility and cost-effectiveness of stroke prevention through community screening for atrial fibrillation using iPhone ECG in pharmacies. The SEARCH-AF study.通过在药房使用iPhone心电图进行社区心房颤动筛查来预防中风的可行性和成本效益。SEARCH-AF研究。
Thromb Haemost. 2014 Jun;111(6):1167-76. doi: 10.1160/TH14-03-0231. Epub 2014 Apr 1.
10
Budget impact analysis of a machine learning algorithm to predict high risk of atrial fibrillation among primary care patients.基于机器学习算法预测基层医疗患者心房颤动高危风险的预算影响分析。
Europace. 2022 Sep 1;24(8):1240-1247. doi: 10.1093/europace/euac016.

引用本文的文献

1
Revisiting the global burden of atrial fibrillation: associations with obesity and the increased risk of stroke.重新审视心房颤动的全球负担:与肥胖及中风风险增加的关联。
Arch Med Sci. 2025 Jun 26;21(3):775-778. doi: 10.5114/aoms/207063. eCollection 2025.
2
Atrial Fibrillation in Asia and Globally: "Easy as ABC," "It's an SOS," or "Handle With CARE".亚洲及全球范围内的心房颤动:“易如ABC”、“这是求救信号”还是“谨慎处理”
JACC Asia. 2025 Jan 21;5(1):125-128. doi: 10.1016/j.jacasi.2024.11.013. eCollection 2025 Jan.
3
The mCHEST Score for Incident Atrial Fibrillation: MESA (Multi-Ethnic Study of Atherosclerosis).

本文引用的文献

1
Screening for Atrial Fibrillation: US Preventive Services Task Force Recommendation Statement.心房颤动筛查:美国预防服务工作组推荐声明。
JAMA. 2022 Jan 25;327(4):360-367. doi: 10.1001/jama.2021.23732.
2
2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary.2021 年亚太心律学会心房颤动卒中预防聚焦更新共识指南:执行摘要。
Thromb Haemost. 2022 Jan;122(1):20-47. doi: 10.1055/s-0041-1739411. Epub 2021 Nov 13.
3
Mobile health solutions for atrial fibrillation detection and management: a systematic review.
新发房颤的mCHEST评分:动脉粥样硬化多族裔研究(MESA)
JACC Adv. 2025 Jan 10;4(2):101521. doi: 10.1016/j.jacadv.2024.101521. eCollection 2025 Feb.
4
Delaying Oral Anticoagulants: A False Economy?延迟使用口服抗凝剂:一种虚假的节约方式?
Pharmacoeconomics. 2024 Nov;42(11):1237-1239. doi: 10.1007/s40273-024-01422-7. Epub 2024 Aug 2.
5
Diagnostic accuracy of digital technologies compared with 12-lead ECG in the diagnosis of atrial fibrillation in adults: A protocol for a systematic review.数字技术与 12 导联心电图诊断成人心房颤动的诊断准确性比较:系统评价方案。
PLoS One. 2024 May 8;19(5):e0301729. doi: 10.1371/journal.pone.0301729. eCollection 2024.
6
Atrial fibrillation: epidemiology, screening and digital health.心房颤动:流行病学、筛查与数字健康。
Lancet Reg Health Eur. 2024 Feb 1;37:100786. doi: 10.1016/j.lanepe.2023.100786. eCollection 2024 Feb.
7
ABC-AF-Stroke score predicts thromboembolism in non-anticoagulated patients following successful atrial fibrillation ablation: a report from the Chinese Atrial Fibrillation Registry.ABC-AF 卒中评分预测非抗凝患者成功房颤消融后的血栓栓塞:来自中国房颤注册研究的报告。
Chin Med J (Engl). 2023 Oct 20;136(20):2451-2458. doi: 10.1097/CM9.0000000000002833. Epub 2023 Sep 11.
8
Electronic health record-wide association study for atrial fibrillation in a British cohort.英国队列中房颤的电子健康记录全基因组关联研究。
Front Cardiovasc Med. 2023 Sep 28;10:1204892. doi: 10.3389/fcvm.2023.1204892. eCollection 2023.
9
Estimating the impact of implementing an integrated care management approach with Atrial fibrillation Better Care (ABC) pathway for patients with atrial fibrillation in England from 2020 to 2040.估计 2020 年至 2040 年在英格兰实施房颤综合护理管理方法(Atrial fibrillation Better Care [ABC] 路径)对房颤患者的影响。
Eur Heart J Qual Care Clin Outcomes. 2024 Jun 20;10(4):326-333. doi: 10.1093/ehjqcco/qcad055.
10
Yield of diagnosis and risk of stroke with screening strategies for atrial fibrillation: a comprehensive review of current evidence.房颤筛查策略的诊断收益与卒中风险:当前证据的全面综述
Eur Heart J Open. 2023 Mar 22;3(2):oead031. doi: 10.1093/ehjopen/oead031. eCollection 2023 Mar.
移动医疗在心房颤动检测和管理中的应用:系统评价。
Clin Res Cardiol. 2022 May;111(5):479-491. doi: 10.1007/s00392-021-01941-9. Epub 2021 Sep 21.
4
"Novel Clinical Concepts in Thrombosis": Integrated Care for Stroke Management-Easy as ABC.“血栓形成的新型临床概念”:卒中管理的综合护理——易如ABC
Thromb Haemost. 2022 Mar;122(3):316-319. doi: 10.1055/a-1632-1777. Epub 2021 Oct 18.
5
Integrated Care Systems and the Aortovascular Hub.综合医疗系统与主动脉血管中心
Thromb Haemost. 2022 Feb;122(2):177-180. doi: 10.1055/a-1591-8033. Epub 2021 Sep 29.
6
Revisiting the dynamic risk profile of cardiovascular/non-cardiovascular multimorbidity in incident atrial fibrillation patients and five cardiovascular/non-cardiovascular outcomes: A machine-learning approach.重新审视初发性房颤患者心血管/非心血管共病的动态风险特征及五种心血管/非心血管结局:一种机器学习方法。
J Arrhythm. 2021 Jun 22;37(4):931-941. doi: 10.1002/joa3.12555. eCollection 2021 Aug.
7
Adherence to the 'Atrial Fibrillation Better Care' Pathway in Patients with Atrial Fibrillation: Impact on Clinical Outcomes-A Systematic Review and Meta-Analysis of 285,000 Patients.房颤患者遵循“房颤优化管理路径”:对 28.5 万名患者临床结局的影响——系统评价和荟萃分析。
Thromb Haemost. 2022 Mar;122(3):406-414. doi: 10.1055/a-1515-9630. Epub 2021 Jun 21.
8
Improving dynamic stroke risk prediction in non-anticoagulated patients with and without atrial fibrillation: comparing common clinical risk scores and machine learning algorithms.改善伴有和不伴有心房颤动的非抗凝患者的动态卒中风险预测:比较常见的临床风险评分和机器学习算法。
Eur Heart J Qual Care Clin Outcomes. 2022 Aug 17;8(5):548-556. doi: 10.1093/ehjqcco/qcab037.
9
Improving Stroke Risk Prediction in the General Population: A Comparative Assessment of Common Clinical Rules, a New Multimorbid Index, and Machine-Learning-Based Algorithms.提高普通人群中风风险预测能力:常见临床规则、新的多病指数和基于机器学习算法的比较评估。
Thromb Haemost. 2022 Jan;122(1):142-150. doi: 10.1055/a-1467-2993. Epub 2021 May 28.
10
Atrial fibrillation in the UK: predicting costs of an emerging epidemic recognizing and forecasting the cost drivers of atrial fibrillation-related costs.英国的心房颤动:预测这一新兴流行病的成本 认识和预测与心房颤动相关成本的成本驱动因素。
Eur Heart J Qual Care Clin Outcomes. 2022 Mar 2;8(2):187-194. doi: 10.1093/ehjqcco/qcaa093.