Chillon Thilo Samson, Maares Maria, Demircan Kamil, Hackler Julian, Sun Qian, Heller Raban A, Diegmann Joachim, Bachmann Manuel, Moghaddam Arash, Haase Hajo, Schomburg Lutz
Institute for Experimental Endocrinology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Department of Food Chemistry and Toxicology, Technische Universität Berlin, Berlin, Germany.
Front Immunol. 2022 Jun 30;13:906551. doi: 10.3389/fimmu.2022.906551. eCollection 2022.
Zinc (Zn) is an essential trace element with high relevance for the immune system, and its deficiency is associated with elevated infection risk and severe disease course. The association of Zn status with the immune response to SARS-CoV-2 vaccination is unknown.
A cohort of adult health care workers (n=126) received two doses of BNT162B2, and provided up to four serum samples over a time course of 6 months. Total SARS-CoV-2 IgG and neutralizing antibody potency was determined, along with total as well as free Zn concentrations.
The SARS-CoV-2 antibodies showed the expected rise in response to vaccination, and decreased toward the last sampling point, with highest levels measured three weeks after the second dose. Total serum Zn concentrations were relatively stable over time, and showed no significant association with SARS-CoV-2 antibodies. Baseline total serum Zn concentration and supplemental intake of Zn were both unrelated to the antibody response to SARS-CoV-2 vaccination. Time resolved analysis of free Zn indicated a similar dynamic as the humoral response. A positive correlation was observed between free Zn concentrations and both the induced antibodies and neutralizing antibody potency.
While the biomarkers of Zn status and supplemental Zn intake appeared unrelated to the humoral immune response to SARS-CoV-2 vaccination, the observed correlation of free Zn to the induced antibodies indicates a diagnostic value of this novel biomarker for the immune system.
锌（Zn）是一种对免疫系统至关重要的微量元素，其缺乏与感染风险升高和疾病进程严重有关。锌状态与针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗接种的免疫反应之间的关联尚不清楚。
一组成年医护人员（n = 126）接种了两剂BNT162B2，并在6个月的时间内提供了多达四份血清样本。测定了SARS-CoV-2总免疫球蛋白G（IgG）和中和抗体效价，以及总锌和游离锌浓度。
SARS-CoV-2抗体在接种疫苗后出现了预期的升高，并在最后一个采样点下降，在第二剂接种后三周测得的水平最高。血清总锌浓度随时间相对稳定，与SARS-CoV-2抗体无显著关联。基线血清总锌浓度和锌的补充摄入量均与SARS-CoV-2疫苗接种的抗体反应无关。对游离锌的时间分辨分析显示出与体液反应相似的动态变化。游离锌浓度与诱导抗体和中和抗体效价之间均观察到正相关。
虽然锌状态的生物标志物和锌的补充摄入量似乎与SARS-CoV-2疫苗接种的体液免疫反应无关，但观察到的游离锌与诱导抗体之间的相关性表明这种新型生物标志物对免疫系统具有诊断价值。
Zotero 插件
