Life Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin 150030, China.
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China.
J Asian Nat Prod Res. 2022 Nov;24(11):1058-1063. doi: 10.1080/10286020.2021.2023505. Epub 2022 Feb 10.
Two previously undescribed cyclopentenone metabolites, ()-2-(3-acetylamino-2-methyl)propyl-3-butyl-2-cyclopenten-1-one () and ()-2-(3-acetylamino-2-ethyl)propyl-3-butyl-2-cyclopenten-1-one (), were isolated from the fermentation broth of the strain sp. HU119. The structures of and were determined by the comprehensive spectroscopic analysis, including 1 D, 2 D NMR, MS spectral analysis and the comparison with data from the literature. The absolute configurations were elucidated by experimental and calculated optical rotations (OR). Compounds and displayed weak cytotoxic activity.
从菌株 sp. HU119 的发酵液中分离得到了两种以前未描述的环戊烯酮代谢物：()-2-(3-乙酰氨基-2-甲基)丙基-3-丁基-2-环戊烯-1-酮 () 和 ()-2-(3-乙酰氨基-2-乙基)丙基-3-丁基-2-环戊烯-1-酮 ()。通过综合光谱分析，包括 1D、2D NMR、MS 光谱分析以及与文献数据的比较，确定了化合物和的结构。通过实验和计算旋光 (OR) 确定了绝对构型。化合物和表现出较弱的细胞毒性活性。
