Qian Ping-Ting, Wang Zhen-Yu, Jia Xiao-He, Zhou Zheng-Ping, Zhang Shao-Yong, Qi Huan, Wang Ji-Dong, Zhang Hui
Zhejiang Hongyuan pharmaceutical co. Ltd, Taizhou, China.
Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insect, College Life Science, Huzhou University, Huzhou, China.
J Antibiot (Tokyo). 2025 Aug 19. doi: 10.1038/s41429-025-00861-4.
A new glycosylated derivative of rausuquinone, rausuquinonoside (1), was isolated from the Tai Lake sediment-derived actinomycete, Streptomyces sp. HU061-2. The structure of 1 was determined by 1D, 2D NMR, MS spectral analysis and the comparison with data from the literature. Bioassay test showed that 1 exhibited potent cytotoxic activity against tumor cell lines HepG2, HCT116 and A549.
从太湖沉积物来源的放线菌链霉菌属HU061-2中分离出了一种新的鸦胆子醌糖基化衍生物——鸦胆子醌苷（1）。通过一维、二维核磁共振、质谱光谱分析以及与文献数据对比确定了1的结构。生物活性测试表明，1对肿瘤细胞系HepG2、HCT116和A549具有较强的细胞毒性活性。
