氨酰-tRNA受限细胞中的移码抑制
Frameshift suppression in aminoacyl-tRNA limited cells.
作者信息
Weiss R B, Gallant J A
出版信息
Genetics. 1986 Apr;112(4):727-39. doi: 10.1093/genetics/112.4.727.
Abstract
Under certain conditions aminoacyl-tRNA limitation can phenotypically suppress frameshift alleles. The observed suppression is due to an increase in abnormal translocation of ribosomes translating codons that have a short supply of aminoacyl-tRNA. The rIIB frameshift alleles of bacteriophage T4 are used here to pinpoint the sites of ribosome frameshifting caused by these hypothetical decoding errors. The data indicate that not all hungry codons are associated with abnormal translocation, only a relatively small subset. Analysis of the hungry codons which are associated with ribosome frameshifting points to the existence of severe context effects determining the shiftiness of these codons.
摘要
在某些条件下，氨酰tRNA限制可在表型上抑制移码等位基因。观察到的抑制作用是由于翻译氨酰tRNA供应不足的密码子的核糖体异常易位增加所致。这里使用噬菌体T4的rIIB移码等位基因来确定由这些假设的解码错误引起的核糖体移码位点。数据表明，并非所有“饥饿”密码子都与异常易位相关，只有相对较小的一部分。对与核糖体移码相关的“饥饿”密码子的分析表明，存在严重的上下文效应决定这些密码子的移码倾向。
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