腹腔内胰岛素输送：从隔室建模看人工胰腺的一种生理途径的证据。
Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling.
机构信息
Department of Woman's and Child's Health, University of Padova, Padova, Italy.
Hôpital Necker-Enfants Malades, Paris, France.
出版信息
J Diabetes Sci Technol. 2023 May;17(3):751-756. doi: 10.1177/19322968221076559. Epub 2022 Feb 10.
BACKGROUND
Intraperitoneal insulin delivery has proven to safely overcome a major limit of subcutaneous delivery-meal announcement-and has been able to optimize glycemic control in adults under controlled experimental conditions. In addition, intraperitoneal delivery avoids peripheral hyperinsulinemia resulting from the subcutaneous route and restores a physiological liver gradient.
METHODS
Relying on a unique data set of intraperitoneal closed-loop insulin delivery obtained with a Model Predictive Controller (MPC), we develop a compartmental model of intraperitoneal insulin kinetics, which, once included in the UVa/Padova T1D simulator, will facilitate the investigation of various control strategies, for example, the simpler Proportional Integral Derivative controller versus MPC.
RESULTS
Intraperitoneal insulin kinetics can be described with a 2-compartment model including liver and plasma.
CONCLUSION
Intraperitoneal insulin transit is fast enough to render irrelevant the addition of a peritoneal compartment, proving the peritoneum being a virtual-not actual-transit space for insulin delivery.
背景
腹腔内胰岛素给药已被证明能够安全地克服皮下给药的一个主要限制——进餐通知，并且能够在受控实验条件下优化成人的血糖控制。此外，腹腔内给药避免了皮下途径引起的外周高胰岛素血症，并恢复了生理肝脏梯度。
方法
我们依靠使用模型预测控制器（MPC）获得的腹腔内闭环胰岛素输送的独特数据集，开发了一个腹腔内胰岛素动力学的隔室模型，该模型一旦包含在 UVa/Padova T1D 模拟器中，将有助于研究各种控制策略，例如，更简单的比例积分微分控制器与 MPC。
结果
腹腔内胰岛素动力学可以用包括肝脏和血浆的 2 隔室模型来描述。
结论
腹腔内胰岛素转运速度足够快，以至于腹膜腔的加入变得无关紧要，证明了腹膜腔对于胰岛素输送来说是一个虚拟的而不是实际的转运空间。
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