Section of Anesthesia, Intensive Care, and Pain Medicine, University Hospital Santa Maria Della Misericordia, Perugia, Italy.
"San Marco" Hospice and Palliative Care, Latina, Italy.
Clin Ter. 2022 Feb 7;173(1):79-83. doi: 10.7417/CT.2022.2396.
Intradermal therapy (mesotherapy) is a technique used to inject drugs into the surface layer of the skin. The intradermal micro deposit allows to modulate the kinetics of drugs, slowing down its absorption and prolonging the local mechanism of action. This technique is applied in the treatment of some forms of localized pain when a systemic drug-saving effect is useful, when it is necessary to synergize with other pharmacological or non-pharmacological thera-pies, when other therapies have failed or cannot be used.
The purpose of our study was to evaluate the effect of a mixture with respect to its lower concentration. We also wanted to evaluate the number of sessions needed to reach the therapeutic goal (50% reduction in pain from baseline) in patients with acute or chronic neck pain.
We analyzed retrospectively data from 62 patients with cervicobrachial pain treated with intradermal drugs. Group A received a mixture of drugs; group B received half the dose of drugs.
Patients who received a lower concentration of drugs achieved similar results to those who received a higher dose. The therapeutic goal was achieved on average with 3.5 + 1.7 sessions on a weekly basis (min 1; max 9). Subjects in group A required 4+1.7 treatments (min 1; max 9), while subjects in group B required 3+1.5 treatments (min 1; max 7).
Our study confirms that even a lower dose of drugs can induce a clinically useful result. This study confirms that the useful effect of mesotherapy is only partly due to the pharmacological action. Further randomized prospective studies are needed to standardize the technique in the various pain syndromes, but it is recommended to follow the guidelines of the Italian Society of Mesotherapy to ensure patients receive appropriate treatment.
皮内治疗（中胚层疗法）是一种将药物注入皮肤表层的技术。皮内微沉积可调节药物的动力学，减缓其吸收并延长局部作用机制。该技术应用于某些形式的局部疼痛治疗，当需要节省全身性药物的效果、需要与其他药理学或非药理学治疗协同作用、其他治疗失败或无法使用时。
我们研究的目的是评估低浓度混合物的效果。我们还想评估达到治疗目标（疼痛从基线降低 50%）所需的疗程数，患者患有急性或慢性颈痛。
我们回顾性分析了 62 例接受皮内药物治疗的颈臂疼痛患者的数据。A 组接受药物混合物；B 组接受药物剂量的一半。
接受低浓度药物的患者与接受高剂量药物的患者取得了相似的结果。每周平均进行 3.5+1.7 次治疗（最小 1 次；最大 9 次）即可达到治疗目标。A 组患者需要 4+1.7 次治疗（最小 1 次；最大 9 次），而 B 组患者需要 3+1.5 次治疗（最小 1 次；最大 7 次）。
我们的研究证实，即使是较低剂量的药物也能产生临床有用的效果。本研究证实，中胚层疗法的有用效果仅部分归因于药理学作用。需要进一步进行随机前瞻性研究来规范各种疼痛综合征中的技术，但建议遵循意大利中胚层疗法学会的指南，以确保患者得到适当的治疗。
