Riha Shaima Maliha, Maarof Manira, Fauzi Mh Busra
Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Polymers (Basel). 2021 May 12;13(10):1546. doi: 10.3390/polym13101546.
Skin tissue engineering has made remarkable progress in wound healing treatment with the advent of newer fabrication strategies using natural/synthetic polymers and stem cells. Stem cell therapy is used to treat a wide range of injuries and degenerative diseases of the skin. Nevertheless, many related studies demonstrated modest improvement in organ functions due to the low survival rate of transplanted cells at the targeted injured area. Thus, incorporating stem cells into biomaterial offer niches to transplanted stem cells, enhancing their delivery and therapeutic effects. Currently, through the skin tissue engineering approach, many attempts have employed biomaterials as a platform to improve the engraftment of implanted cells and facilitate the function of exogenous cells by mimicking the tissue microenvironment. This review aims to identify the limitations of stem cell therapy in wound healing treatment and potentially highlight how the use of various biomaterials can enhance the therapeutic efficiency of stem cells in tissue regeneration post-implantation. Moreover, the review discusses the combined effects of stem cells and biomaterials in in vitro and in vivo settings followed by identifying the key factors contributing to the treatment outcomes. Apart from stem cells and biomaterials, the role of growth factors and other cellular substitutes used in effective wound healing treatment has been mentioned. In conclusion, the synergistic effect of biomaterials and stem cells provided significant effectiveness in therapeutic outcomes mainly in wound healing improvement.
随着使用天然/合成聚合物和干细胞的新型制造策略的出现，皮肤组织工程在伤口愈合治疗方面取得了显著进展。干细胞疗法用于治疗多种皮肤损伤和退行性疾病。然而，许多相关研究表明，由于移植细胞在目标损伤区域的存活率较低，器官功能的改善并不明显。因此，将干细胞整合到生物材料中为移植的干细胞提供了微环境，提高了它们的递送和治疗效果。目前，通过皮肤组织工程方法，许多尝试将生物材料作为一个平台，通过模拟组织微环境来改善植入细胞的植入并促进外源细胞的功能。本综述旨在确定干细胞疗法在伤口愈合治疗中的局限性，并可能强调如何使用各种生物材料提高干细胞在植入后组织再生中的治疗效率。此外，该综述讨论了干细胞和生物材料在体外和体内环境中的联合作用，随后确定了影响治疗结果的关键因素。除了干细胞和生物材料外，还提到了生长因子和其他用于有效伤口愈合治疗的细胞替代物的作用。总之，生物材料和干细胞的协同作用在治疗结果中提供了显著的有效性，主要体现在伤口愈合的改善上。
