Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
Department of Pharmaceutical Engineering, Dankook University, Cheonan 31116, Korea.
Int J Mol Sci. 2021 May 22;22(11):5487. doi: 10.3390/ijms22115487.
Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques.
细胞外囊泡 (EV) 在细胞间传递货物，如核酸、蛋白质和脂质，并充当细胞间的通讯器。由于大多数与 EV 相关的功能都与免疫反应密切相关，因此 EV 在炎症性疾病中的重要作用正在显现。可以通过 EV 表面工程对 EV 进行功能化，并赋予靶向部分，从而实现治疗炎症性疾病的靶向特异性。此外，工程化 EV 被认为是开发个性化治疗载体的有前途的纳米颗粒。在这篇综述中，我们强调了 EV 在各种炎症性疾病中的作用、EV 作为抗炎治疗剂的应用以及 EV 工程技术的最新进展。
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