Presentation and Immune Regulation Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
Front Immunol. 2022 Jan 28;13:832889. doi: 10.3389/fimmu.2022.832889. eCollection 2022.
The potential effect of emerging SARS-CoV-2 variants on vaccine efficacy is an issue of critical importance. In this study, the possible impact of mutations that facilitate virus escape from the cytotoxic and the helper cellular immune responses in the new SARS-CoV-2 Omicron variant of concern was analyzed for the 551 and 41 most abundant HLA class I and II alleles, respectively. Computational prediction showed that almost all of these 592 alleles, which cover 90% of the human population, contain enough epitopes without escape mutations in the emerging SARS-CoV-2 Omicron variant of concern. These data suggest that both cytotoxic and helper cellular immune protection elicited by currently licensed vaccines are virtually unaffected by the highly contagious SARS-CoV-2 Omicron variant of concern.
新型 SARS-CoV-2 变体对疫苗效力的潜在影响是一个至关重要的问题。在这项研究中，分析了新出现的 SARS-CoV-2 关注变体奥密克戎中有助于病毒逃避细胞毒性和辅助性细胞免疫反应的突变对 551 个和 41 个最丰富的 HLA Ⅰ类和Ⅱ类等位基因的可能影响。计算预测表明，这些涵盖 90%人口的 592 个等位基因中，几乎所有的等位基因都含有足够的表位，而在新出现的 SARS-CoV-2 关注变体奥密克戎中没有逃逸突变。这些数据表明，目前授权的疫苗所引起的细胞毒性和辅助性细胞免疫保护几乎不受高传染性的 SARS-CoV-2 关注变体奥密克戎的影响。
