通过网络分析探索紫外激光辐射对基因表达谱的可逆影响。
Exploring the Reversible Effects of UV Laser Radiation on the Gene Expression Profiles of Via Network Analysis.
作者信息
Vafaee Reza, Safari-Alighiarloo Nahid, Razzaghi Zahra, Ansari Mojtaba, Rostami Nejad Mohammad, Hamdieh Mostafa, Mansouri Vahid
机构信息
Critical Care Quality Improvement Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
出版信息
J Lasers Med Sci. 2021 Dec 29;12:e90. doi: 10.34172/jlms.2021.90. eCollection 2021.
The reversibility of biological processes is an important challenge in the study of environmental pollutants and also natural and artificial radiation. There are many pieces of evidence about the reversible and irreversible effects of UV radiation on the human body. Assessment of the reversibility of UV laser effects on was the aim of this study. Gene expression alteration in samples radiated by a 30s UV laser for 15, 30, and 60 minutes post-radiation times were investigated via network analysis to explore time-dependent reversible alteration in the gene expression profiles of the samples. 19 differentially expressed genes (DEGs) were identified as targeted genes for the samples which were harvested 60 minutes after radiation; network analysis revealed no significant alteration in biological processes. It can be concluded that the gross effects of the UV laser on samples disappear after 60 minutes of radiation.
生物过程的可逆性是环境污染物以及天然和人工辐射研究中的一项重要挑战。有许多证据表明紫外线辐射对人体具有可逆和不可逆的影响。本研究的目的是评估紫外线激光对[具体对象未明确]的影响的可逆性。通过网络分析研究了在辐射后15、30和60分钟时，经30秒紫外线激光辐射的[具体对象未明确]样本中的基因表达变化，以探索样本基因表达谱中随时间变化的可逆性改变。确定了19个差异表达基因（DEG）作为辐射后60分钟收获的样本的靶向基因；网络分析显示生物过程无显著变化。可以得出结论，紫外线激光对[具体对象未明确]样本的总体影响在辐射60分钟后消失。
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