Lucht U, Bünger C, Møller J T, Joyce F, Plenk H
Acta Orthop Scand. 1986 Feb;57(1):19-24. doi: 10.3109/17453678608993208.
To study bone formation and regional blood flow following the use of fibrin sealant in autologous cancellous bone transplantation, a dog model was developed. In 18 dogs, a standardized defect in both tibiae was filled with an autologous iliac crest graft. On one side, the bone chips were mixed with fibrin sealant while the other side served as control. After 1, 2 and 3 weeks the blood flow of the transplant was calculated and the new bone formed evaluated histomorphometrically. Generally, the highest blood flow rates and most intensive new bone formation were observed at 2 weeks postoperatively. Fibrin sealant did not alter blood flow or new bone formation, but a tendency to diminished new bone formation was found in some grafts. Our study does not support the application of fibrin sealant in ordinary cancellous bone grafting.
为研究自体松质骨移植中使用纤维蛋白封闭剂后的骨形成和局部血流情况，建立了犬模型。在18只犬中，双侧胫骨制造标准化缺损，用自体髂嵴移植骨填充。一侧骨屑与纤维蛋白封闭剂混合，另一侧作为对照。术后1、2和3周计算移植部位的血流，并通过组织形态计量学评估新形成的骨。一般来说，术后2周观察到最高的血流速率和最强烈的新骨形成。纤维蛋白封闭剂未改变血流或新骨形成，但在一些移植物中发现新骨形成有减少的趋势。我们的研究不支持在普通松质骨移植中应用纤维蛋白封闭剂。
