Radiobiology and Health, Canadian Nuclear Laboratories (CNL), Chalk River, ON K0J 1J0, Canada.
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Cells. 2022 Jan 21;11(3):356. doi: 10.3390/cells11030356.
Cells exposed to ionizing radiation undergo a series of complex responses, including DNA damage, reproductive cell death, and altered proliferation states, which are all linked to cell cycle dynamics. For many years, a great deal of research has been conducted on cell cycle checkpoints and their regulators in mammalian cells in response to high-dose exposures to ionizing radiation. However, it is unclear how low-dose ionizing radiation (LDIR) regulates the cell cycle progression. A growing body of evidence demonstrates that LDIR may have profound effects on cellular functions. In this review, we summarize the current understanding of how LDIR (of up to 200 mGy) regulates the cell cycle and cell-cycle-associated proteins in various cellular settings. In light of current findings, we also illustrate the conceptual function and possible dichotomous role of p21, a transcriptional target of p53, in response to LDIR.
暴露于电离辐射的细胞会经历一系列复杂的反应，包括 DNA 损伤、生殖细胞死亡和增殖状态改变，这些都与细胞周期动力学有关。多年来，人们对哺乳动物细胞在高剂量电离辐射下的细胞周期检查点及其调节因子进行了大量研究。然而，低剂量电离辐射（LDIR）如何调节细胞周期进程尚不清楚。越来越多的证据表明，LDIR 可能对细胞功能产生深远影响。在这篇综述中，我们总结了目前对 LDIR（高达 200mGy）如何调节各种细胞环境中的细胞周期和细胞周期相关蛋白的理解。鉴于目前的发现，我们还说明了 p21（p53 的转录靶标）在响应 LDIR 时的概念功能和可能的二分角色。
