Matuszak Natalia, Piotrowski Igor, Kruszyna-Mochalska Marta, Skrobala Agnieszka, Mocydlarz-Adamcewicz Mirosława, Malicki Julian
Department of Electroradiology, Poznan University of Medical Sciences, Poznan, Poland.
Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Poznan, Poland.
Rep Pract Oncol Radiother. 2024 Dec 4;29(5):638-648. doi: 10.5603/rpor.103525. eCollection 2024.
The biological effects and clinical consequences of out-of-field radiation in peripheral organs can be difficult to determine, especially for low doses (0.1 Gy-1 Gy). In recent years, Monte Carlo (MC) methods have been proposed to more accurately predict nontarget doses. The aim of the present study was to assess the feasibility of using Monte Carlo methods to predict the biological response of tissues and critical organs to low dose radiation (0.1 to 1 Gy) based on results published in the literature.
Literature review, including studies published by our group.
It has long been assumed that radiation doses to peripheral organs located far from the target volume are too low to have any clinical impact. In recent years, however, concerns about the risk of treatment-induced secondary cancers, even in peripheral organs, have continued to grow in line with increasing life expectancy. At present, it is difficult in routine calculations to accurately determine radiation doses to the whole body and peripheral organs. Moreover, the potential clinical impact of these doses remains uncertain and the biological response to low dose radiation depends on the organ. In this context, MC methods can predict biological response in those organs. Monte Carlo methods have become a powerful tool to better predict the consequences of interactions between ionising radiation and biological matter. MC modelling can also help to characterise microscopic system dynamics and to provide a better understanding of processes occurring at the cellular, molecular, and nanoscales.
外周器官中射野外辐射的生物学效应和临床后果可能难以确定，尤其是对于低剂量（0.1戈瑞 - 1戈瑞）而言。近年来，已提出蒙特卡罗（MC）方法以更准确地预测非靶区剂量。本研究的目的是根据文献发表的结果评估使用蒙特卡罗方法预测组织和关键器官对低剂量辐射（0.1至1戈瑞）的生物学反应的可行性。
文献综述，包括我们团队发表的研究。
长期以来人们一直认为，位于远离靶区的外周器官所接受的辐射剂量过低，不会产生任何临床影响。然而，近年来，随着预期寿命的增加，即使是对外周器官中治疗诱发继发性癌症风险的担忧也在持续增加。目前，在常规计算中难以准确确定全身和外周器官的辐射剂量。此外，这些剂量的潜在临床影响仍不确定，并且对低剂量辐射的生物学反应取决于器官。在此背景下，MC方法可以预测这些器官中的生物学反应。蒙特卡罗方法已成为更好地预测电离辐射与生物物质之间相互作用后果的有力工具。MC建模还有助于表征微观系统动力学，并更好地理解在细胞、分子和纳米尺度上发生的过程。
