既往感染对感染新型冠状病毒2的急诊科患者入住重症监护病房及死亡率无影响。
No Influence of Previous Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2.
作者信息
Weehuizen Jesper M, van Spronsen Rik, Hoepelman Andy I M, Bleeker-Rovers Chantal P, Oosterheert Jan Jelrik, Wever Peter C
机构信息
Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Department of Internal Medicine and Infectious Diseases, Radboud Expertise Center for Q Fever, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
出版信息
J Clin Med. 2022 Jan 20;11(3):526. doi: 10.3390/jcm11030526.
BACKGROUND
the geographical similarities of the Dutch 2007-2010 Q fever outbreak and the start of the 2020 coronavirus disease 19 (COVID-19) outbreak in the Netherlands raised questions and provided a unique opportunity to study an association between infection and the outcome following SARS-CoV-2 infection.
METHODS
We performed a retrospective cohort study in two Dutch hospitals. We assessed evidence of previous infection in COVID-19 patients diagnosed at the ED during the first COVID-19 wave and compared a combined outcome of in-hospital mortality and intensive care unit (ICU) admission using adjusted odds ratios (OR).
RESULTS
In total, 629 patients were included with a mean age of 68.0 years. Evidence of previous infection was found in 117 patients (18.6%). The combined primary outcome occurred in 40.2% and 40.4% of patients with and without evidence of previous infection respectively (adjusted OR of 0.926 (95% CI 0.605-1.416)). The adjusted OR of the secondary outcomes in-hospital mortality, ICU-admission and regular ward admission did not show an association either.
CONCLUSION
no influence of previous infection on the risk of ICU admission and/or mortality for patients with COVID-19 presenting at the ED was observed.
背景
荷兰2007 - 2010年Q热疫情的地理分布情况与2020年荷兰冠状病毒病19（COVID - 19）疫情的起始情况存在相似之处，这引发了诸多问题，并提供了一个独特的机会来研究感染与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染后结局之间的关联。
方法
我们在荷兰的两家医院进行了一项回顾性队列研究。我们评估了在第一波COVID - 19疫情期间于急诊科确诊的COVID - 19患者既往感染的证据，并使用调整后的比值比（OR）比较了住院死亡率和重症监护病房（ICU）收治率的综合结局。
结果
总共纳入了629例患者，平均年龄为68.0岁。在117例患者（18.6%）中发现了既往感染的证据。有和没有既往感染证据的患者中，综合主要结局的发生率分别为40.2%和40.4%（调整后的OR为0.926（95%可信区间0.605 - 1.416））。次要结局中的住院死亡率、ICU收治率和普通病房收治率的调整后OR也未显示出关联。
结论
未观察到既往感染对在急诊科就诊的COVID - 19患者的ICU收治风险和/或死亡率有影响。
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