Hiraoka Takahiro, Asano Hiroki, Ogami Tomohiro, Nakano Shinichiro, Okamoto Yoshifumi, Yamada Yoshiaki, Oshika Tetsuro
Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Department of Ophthalmology, Tsuchiura Kyodo General Hospital Namegata District Medical Center, Tsuchiura 311-3516, Japan.
J Clin Med. 2022 Jan 28;11(3):710. doi: 10.3390/jcm11030710.
The influence of dry eye disease (DED) on ocular biometric measurements is unclear. We aimed to investigate the effect of DED on the repeatability of ocular biometric measurements in cataract patients. Overall, 114 eyes scheduled for cataract surgery were enrolled. Before surgery, DED parameters including tear film break-up time (BUT), corneal and conjunctival staining scores, and subjective symptoms were examined. Corneal curvature radius and axial length were assessed twice on the same day using IOLMaster-500 (Carl Zeiss Meditec), and the absolute difference between the two measurements was calculated and used as an index of measurement repeatability. The measurement repeatability of the steep meridian of corneal curvature radius was significantly worse in eyes with DED than in those without DED ( = 0.044) and was significantly associated with BUT (r = -0.206, = 0.031). The measurement repeatability of axial length was negatively correlated with BUT (r = -0.199, = 0.041) and positively correlated with the corneal staining score (r = 0.253, = 0.009). In conclusion, the measurement repeatability of corneal curvature radius declined in eyes with DED. Shortened BUTs were associated with a deterioration in the measurement repeatability of corneal curvature radius and axial length.
干眼疾病（DED）对眼部生物测量的影响尚不清楚。我们旨在研究DED对白内障患者眼部生物测量重复性的影响。总共纳入了114只计划进行白内障手术的眼睛。手术前，检查了干眼参数，包括泪膜破裂时间（BUT）、角膜和结膜染色评分以及主观症状。使用IOLMaster-500（卡尔·蔡司医疗技术公司）在同一天对角膜曲率半径和眼轴长度进行了两次评估，并计算了两次测量之间的绝对差值，将其用作测量重复性的指标。DED患者角膜曲率半径陡峭子午线的测量重复性明显低于无DED患者（P = 0.044），且与BUT显著相关（r = -0.206，P = 0.031）。眼轴长度的测量重复性与BUT呈负相关（r = -0.199，P = 0.041），与角膜染色评分呈正相关（r = 0.253，P = 0.009）。总之，DED患者角膜曲率半径的测量重复性下降。BUT缩短与角膜曲率半径和眼轴长度测量重复性的恶化有关。
