Gharibkandi Nasrin Abbasi, Gierałtowska Joanna, Wawrowicz Kamil, Bilewicz Aleksander
Institute of Nuclear Chemistry and Technology, 03-195 Warsaw, Poland.
Materials (Basel). 2022 Feb 1;15(3):1143. doi: 10.3390/ma15031143.
The concept of nanoparticle-mediated radionuclide delivery in the cancer treatment has been widely discussed in the past decade. In particular, the use of inorganic and organic nanostructures in the development of radiopharmaceuticals enables the delivery of medically important radioisotopes for radionuclide therapy. In this review, we present the development of nanostructures for cancer therapy with Auger electron radionuclides. Following that, different types of nanoconstructs that can be used as carriers for Auger electron emitters, design principles, nanoparticle materials, and target vectors that overcame the main difficulties are described. In addition, systems in which high-Z element nanoparticles are used as radionuclide carriers, causing the emission of photoelectrons from the nanoparticle surface, are presented. Finally, future research opportunities in the field are discussed as well as issues that must be addressed before nanoparticle-based Auger electron radionuclide therapy can be transferred to clinical use.
在过去十年中，纳米颗粒介导的放射性核素递送用于癌症治疗的概念已得到广泛讨论。特别是，无机和有机纳米结构在放射性药物开发中的应用使得医学上重要的放射性同位素能够用于放射性核素治疗。在本综述中，我们介绍了用于俄歇电子放射性核素癌症治疗的纳米结构的发展。接下来，描述了可用作俄歇电子发射体载体的不同类型的纳米构建体、设计原则、纳米颗粒材料以及克服主要困难的靶向载体。此外，还介绍了使用高Z元素纳米颗粒作为放射性核素载体，导致纳米颗粒表面发射光电子的系统。最后，讨论了该领域未来的研究机会以及在基于纳米颗粒的俄歇电子放射性核素治疗能够转化为临床应用之前必须解决的问题。
