Su Weiwei, Wang Han, Wang Tao, Li Xiao, Tang Zhongmin, Zhao Shuai, Zhang Meng, Li Danni, Jiang Xingwu, Gong Teng, Yang Wei, Zuo Changjing, Wu Yelin, Bu Wenbo
Department of Nuclear Medicine Changhai Hospital Naval Medical University Shanghai 200433 P. R. China.
University of Chinese Academy of Sciences Beijing 100049 P. R. China.
Adv Sci (Weinh). 2020 Apr 6;7(10):1903585. doi: 10.1002/advs.201903585. eCollection 2020 May.
Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (I) are used in situ to construct active sites in a nanocatalyst (TiO) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). The obtained I-TiO nanoparticles first construct superficial Ti active sites via the reaction between Ti and AEs. Then Ti stretches and weakens the O-H bond of the absorbed HO, thus enhancing the radiolysis of HO molecules and generating hydroxyl radicals (•OH). All in vitro and in vivo results demonstrate a good CIRT performance. These findings will broaden the application of radionuclides and introduce new perspectives to nanomedicine.
过量电子在纳米催化剂表面活性位点的构建中起着重要作用。然而，在体内向纳米催化剂提供过量电子仍然是一个挑战，这限制了纳米催化剂在生物医学中的应用。在此，利用放射性核素125（I）发射的俄歇电子（AE）原位构建纳米催化剂（TiO）中的活性位点，并将该方法的应用进一步扩展到癌症催化内放射治疗（CIRT）。所获得的I-TiO纳米颗粒首先通过Ti与AE之间的反应构建表面Ti活性位点。然后Ti拉伸并削弱吸附的HO的O-H键，从而增强HO分子的辐射分解并产生羟基自由基（•OH）。所有体外和体内结果均显示出良好的CIRT性能。这些发现将拓宽放射性核素的应用范围，并为纳米医学引入新的视角。
