Center for Bioenergetics, Houston Methodist Research Institute, Houston, TX 77030, USA.
Xiangya Hospital, Central South University, Changsha 410008, China.
Int J Mol Sci. 2022 Jan 18;23(3):1010. doi: 10.3390/ijms23031010.
Calcium signaling plays important roles in physiological and pathological conditions, including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium concentration ([Ca]i), cell membrane calcium channels, calcium related proteins (S100 family, E-cadherin, and calpain), and Wnt/Ca pathways are related to melanogenesis and melanoma tumorigenesis and progression. Calcium signaling influences the melanoma microenvironment, including immune cells, extracellular matrix (ECM), the vascular network, and chemical and physical surroundings. Other ionic channels, such as sodium and potassium channels, are engaged in calcium-mediated pathways in melanoma. Calcium signaling serves as a promising pharmacological target in melanoma treatment, and its dysregulation might serve as a marker for melanoma prediction. We documented calcium-dependent endoplasmic reticulum (ER) stress and mitochondria dysfunction, by targeting calcium channels and influencing [Ca]i and calcium homeostasis, and attenuated drug resistance in melanoma management.
钙信号在生理和病理条件中发挥着重要作用，包括皮肤黑色素瘤，这是最致命的皮肤癌类型。细胞内钙离子浓度([Ca]i)、细胞膜钙通道、钙相关蛋白（S100 家族、E-钙黏蛋白和钙蛋白酶）和 Wnt/Ca 途径与黑色素生成和黑色素瘤的发生和进展有关。钙信号影响黑色素瘤微环境，包括免疫细胞、细胞外基质 (ECM)、血管网络以及化学和物理环境。其他离子通道，如钠和钾通道，参与黑色素瘤中的钙介导途径。钙信号是黑色素瘤治疗中一个有前途的药理学靶点，其失调可能成为黑色素瘤预测的标志物。我们通过靶向钙通道、影响[Ca]i 和钙稳态，记录了钙依赖性内质网 (ER) 应激和线粒体功能障碍，并减轻了黑色素瘤管理中的药物耐药性。
