半红树植物 A. Gray 中的抗耐甲氧西林金黄色葡萄球菌倍半萜
Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant A. Gray.
机构信息
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China.
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
出版信息
Mar Drugs. 2018 Nov 8;16(11):438. doi: 10.3390/md16110438.
The striking rise of methicillin-resistant (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant A. Gray, which led to the isolation of two new sesquiterpene alkaloids ( and ) and six known furanosesquiterpenes (⁻). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids ( and ) displayed potent anti-MRSA activity with MIC value of 6.25 μg/mL. This is the first report of sesquiterpene alkaloids from the plants of genus and their anti-MRSA activity.
耐甲氧西林金黄色葡萄球菌（MRSA）感染的惊人上升已成为全球公共卫生的严重威胁。为了从天然产物中寻找新的抗 MRSA 药物，对半红树林植物 A. Gray 进行了生物测定指导的植物化学研究，从中分离得到了两种新的倍半萜生物碱（和）和六种已知的呋喃倍半萜（⁻）。基于对它们的 1D、2D NMR 和质谱数据的广泛分析，阐明了它们的结构。这两种新的生物碱（和）表现出很强的抗 MRSA 活性，MIC 值为 6.25 μg/mL。这是首次从属植物中分离到倍半萜生物碱及其抗 MRSA 活性的报道。
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