Division of General Internal Medicine, Jackson Memorial Hospital, Miami, FL, USA.
Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA.
BMC Res Notes. 2022 Feb 14;15(1):52. doi: 10.1186/s13104-022-05934-3.
Abnormal thyroid function may disrupt sleep architecture. We aimed to determine the frequency of various chronotypes in women with hypothyroidism. We performed a single-center retrospective study at an ambulatory clinic from January 2013-December 2015. Participants were women with hypothyroidism. Chronotype was determined from the Munich ChronoType Questionnaire. The χ test was used to compare differences in clinical characteristics and sleep patterns in early and intermediate/late chronotypes. The t test was used to compare differences between means.
We evaluated 99 patients (mean [SD], 56 [7] years): calculated chronotype revealed: 56% early, 38% intermediate and 6% late. Analysis with the χ test showed significant differences between early and intermediate/late calculated chronotypes for sleep latency (P = 0.01), light exposure (P = 0.009), and no alcohol intake (P = 0.001). t test showed the following differences in mean (SD) between chronotypes: sleep duration, 7.30 (1.39) hours (early chronotype) and 7.04 (2.06) hours (intermediate/late); body mass index (BMI), 29.4 (7.3) (early) and 31.1 (6.8) (intermediate/late); and TSH level, 2.89 (3.69) mIU/L (early) and 1.69 (1.41) mIU/L (intermediate/late). Early chronotypes were frequent in women with hypothyroidism. Light exposure and BMI may influence chronotypes in patients with hypothyroidism; findings are consistent with healthier behaviors in patients who tend toward morningness.
甲状腺功能异常可能会破坏睡眠结构。我们旨在确定甲状腺功能减退症女性中各种类型的出现频率。我们在 2013 年 1 月至 2015 年 12 月期间在一家门诊诊所进行了一项单中心回顾性研究。参与者为甲状腺功能减退症女性。通过慕尼黑时间类型问卷确定时间类型。使用 χ 检验比较早型和中/晚型之间的临床特征和睡眠模式差异。使用 t 检验比较平均值之间的差异。
我们评估了 99 名患者(平均[标准差],56[7]岁):计算出的时间类型为:56%为早型,38%为中/晚型。χ 检验分析显示,在睡眠潜伏期(P=0.01)、光照暴露(P=0.009)和无饮酒(P=0.001)方面,早型和中/晚型之间存在显著差异。t 检验显示时间类型之间的平均(标准差)差异如下:睡眠时间,7.30(1.39)小时(早型)和 7.04(2.06)小时(中/晚型);体重指数(BMI),29.4(7.3)(早型)和 31.1(6.8)(中/晚型);和 TSH 水平,2.89(3.69)mIU/L(早型)和 1.69(1.41)mIU/L(中/晚型)。早型在甲状腺功能减退症女性中较为常见。光照暴露和 BMI 可能影响甲状腺功能减退症患者的时间类型;这些发现与倾向于早起的患者更健康的行为一致。