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成年女性原发性甲状腺功能减退症与昼夜类型。

Primary hypothyroidism and chronotypes in adult women.

机构信息

Division of General Internal Medicine, Jackson Memorial Hospital, Miami, FL, USA.

Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA.

出版信息

BMC Res Notes. 2022 Feb 14;15(1):52. doi: 10.1186/s13104-022-05934-3.

Abstract

OBJECTIVE

Abnormal thyroid function may disrupt sleep architecture. We aimed to determine the frequency of various chronotypes in women with hypothyroidism. We performed a single-center retrospective study at an ambulatory clinic from January 2013-December 2015. Participants were women with hypothyroidism. Chronotype was determined from the Munich ChronoType Questionnaire. The χ test was used to compare differences in clinical characteristics and sleep patterns in early and intermediate/late chronotypes. The t test was used to compare differences between means.

RESULTS

We evaluated 99 patients (mean [SD], 56 [7] years): calculated chronotype revealed: 56% early, 38% intermediate and 6% late. Analysis with the χ test showed significant differences between early and intermediate/late calculated chronotypes for sleep latency (P = 0.01), light exposure (P = 0.009), and no alcohol intake (P = 0.001). t test showed the following differences in mean (SD) between chronotypes: sleep duration, 7.30 (1.39) hours (early chronotype) and 7.04 (2.06) hours (intermediate/late); body mass index (BMI), 29.4 (7.3) (early) and 31.1 (6.8) (intermediate/late); and TSH level, 2.89 (3.69) mIU/L (early) and 1.69 (1.41) mIU/L (intermediate/late). Early chronotypes were frequent in women with hypothyroidism. Light exposure and BMI may influence chronotypes in patients with hypothyroidism; findings are consistent with healthier behaviors in patients who tend toward morningness.

摘要

目的

甲状腺功能异常可能会破坏睡眠结构。我们旨在确定甲状腺功能减退症女性中各种类型的出现频率。我们在 2013 年 1 月至 2015 年 12 月期间在一家门诊诊所进行了一项单中心回顾性研究。参与者为甲状腺功能减退症女性。通过慕尼黑时间类型问卷确定时间类型。使用 χ 检验比较早型和中/晚型之间的临床特征和睡眠模式差异。使用 t 检验比较平均值之间的差异。

结果

我们评估了 99 名患者(平均[标准差],56[7]岁):计算出的时间类型为:56%为早型,38%为中/晚型。χ 检验分析显示,在睡眠潜伏期(P=0.01)、光照暴露(P=0.009)和无饮酒(P=0.001)方面,早型和中/晚型之间存在显著差异。t 检验显示时间类型之间的平均(标准差)差异如下:睡眠时间,7.30(1.39)小时(早型)和 7.04(2.06)小时(中/晚型);体重指数(BMI),29.4(7.3)(早型)和 31.1(6.8)(中/晚型);和 TSH 水平,2.89(3.69)mIU/L(早型)和 1.69(1.41)mIU/L(中/晚型)。早型在甲状腺功能减退症女性中较为常见。光照暴露和 BMI 可能影响甲状腺功能减退症患者的时间类型;这些发现与倾向于早起的患者更健康的行为一致。

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