Neurologic Unit, AOU "Policlinico-San Marco", Department of Medical, Surgical Sciences and Advanced Technologies, GF Ingrassia, University of Catania, Via Santa Sofia n.78, 95100, Catania, Sicily, Italy.
Sci Rep. 2022 Feb 14;12(1):2401. doi: 10.1038/s41598-022-06424-z.
Rapid eye movement sleep behavior disorder (RBD) is a common prodromic non-motor symptom of Parkinson's disease (PD). Only few studies have evaluated the personality of RBD patients with conflicting results. Aim of the study was to evaluate the frequency of Personality Disorders (PeDs)in RBD. RBD patients, PD patients and healthy controls (HC) were enrolled. All the enrolled subjects underwent a full neurological examination. Motor symptoms were evaluated with the UPDRS-Motor Examination. PeDs were assessed with the Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II). Twenty-nine RBD patients [14 men (48.3%); mean age 55.6 ± 11.1], 30 PD patients [17 men (56.7%); mean age 65.7 ± 10.7] and 30 HC [12 men (40%); mean age 65.7 ± 5.4] were enrolled in the study. PD patients had a disease duration of 4.5 ± 4.6 and presented a mean UPDRS-ME score of 26.7 ± 9.4. The most frequent PeDs was the Obsessive-Compulsive one (OCPeD); OCPeD was significantly more frequent in RBD (55.2%) patients than HC (13.3%; p-value < 0.001). No significant differences were found comparing the frequency of OCPeD in RBD patients to that in PD. In the present study, the prevalence of OCPeD in RBD patients was close to that reported in PD patients. Our data could suggest the existence of a common disease-specific RBD-PD personality profile.
快速眼动睡眠行为障碍（RBD）是帕金森病（PD）的常见前驱非运动症状。仅有少数研究评估了 RBD 患者的人格，结果存在争议。本研究旨在评估 RBD 患者中人格障碍（PeD）的频率。招募了 RBD 患者、PD 患者和健康对照者（HC）。所有入组的受试者均接受了全面的神经系统检查。运动症状采用 UPDRS-运动检查进行评估。PeD 采用 DSM-IV 人格障碍结构化临床访谈（SCID-II）进行评估。29 名 RBD 患者[14 名男性（48.3%）；平均年龄 55.6±11.1]、30 名 PD 患者[17 名男性（56.7%）；平均年龄 65.7±10.7]和 30 名 HC[12 名男性（40%）；平均年龄 65.7±5.4]纳入本研究。PD 患者的病程为 4.5±4.6 年，UPDRS-ME 评分为 26.7±9.4。最常见的 PeD 是强迫症（OCPeD）；RBD（55.2%）患者的 OCPeD 明显多于 HC（13.3%）（p 值<0.001）。RBD 患者的 OCPeD 频率与 PD 患者无显著差异。在本研究中，RBD 患者 OCPeD 的患病率接近 PD 患者。我们的数据表明，存在一种与 RBD-PD 相关的共同疾病特异性人格特征。
