Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
Hai Ba Trung High School, Hue City, Vietnam.
Anal Methods. 2022 Feb 24;14(8):850-858. doi: 10.1039/d1ay02152d.
Using waste materials to extract biologically active ingredients with green solvents is a new trend for sustainable development. Herein, different types of deep eutectic solvents (DESs) and surfactant solvents (SSs) were used to extract curcumin from turmeric residues (TRs), among which choline chloride-propylene glycol (ChCl-Pro) showed the highest yield. The optimized extraction conditions included a ChCl : Pro ratio of 1 : 2, water content in the DESs of 20%, solid : liquid ratio of 1 : 40 maintained for 60 min at 50 °C, and a TR particle size of 0.18 mm. The extraction yield was 54.2 mg g, which was 1.31 times higher than when methanol was used as a solvent. Distilled water was used to recover curcumin from the DES extract with a recovery yield of 99.7%. Furthermore, the antioxidant and acetylcholinesterase (AChE) inhibitory activities of the recovered curcumin were evaluated, with IC values of 25.58 ± 0.51 and 19.12 ± 0.83 μg mL, respectively. This study highlights the promising potential of using green solvents to extract bioactive compounds from waste materials.
利用绿色溶剂从废料中提取具有生物活性的成分是可持续发展的新趋势。本文使用不同类型的深共晶溶剂（DESs）和表面活性剂溶剂（SSs）从姜黄渣（TRs）中提取姜黄素，其中氯化胆碱-丙二醇（ChCl-Pro）表现出最高的产率。优化的提取条件包括 ChCl:Pro 比例为 1:2、DES 中水含量为 20%、固液比为 1:40，在 50°C 下保持 60 分钟，TR 粒径为 0.18mm。提取产率为 54.2mg/g，是甲醇作为溶剂时的 1.31 倍。用蒸馏水从 DES 提取物中回收姜黄素，回收率为 99.7%。此外，还评估了回收姜黄素的抗氧化和乙酰胆碱酯酶（AChE）抑制活性，IC 值分别为 25.58±0.51μg/mL 和 19.12±0.83μg/mL。本研究强调了利用绿色溶剂从废料中提取生物活性化合物的广阔前景。
